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Interleukin-6 in renal disease and therapy.
Jones SA, Fraser DJ, Fielding CA, Jones GW. Jones SA, et al. Among authors: jones gw. Nephrol Dial Transplant. 2015 Apr;30(4):564-74. doi: 10.1093/ndt/gfu233. Epub 2014 Jul 10. Nephrol Dial Transplant. 2015. PMID: 25011387 Review.
Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.
Lissilaa R, Buatois V, Magistrelli G, Williams AS, Jones GW, Herren S, Shang L, Malinge P, Guilhot F, Chatel L, Hatterer E, Jones SA, Kosco-Vilbois MH, Ferlin WG. Lissilaa R, et al. Among authors: jones gw, jones sa. J Immunol. 2010 Nov 1;185(9):5512-21. doi: 10.4049/jimmunol.1002015. Epub 2010 Sep 24. J Immunol. 2010. PMID: 20870936
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J. Garbers C, et al. Among authors: jones gw, jones sa. J Biol Chem. 2011 Dec 16;286(50):42959-70. doi: 10.1074/jbc.M111.295758. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990364 Free PMC article.
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
Orr SJ, Burg AR, Chan T, Quigley L, Jones GW, Ford JW, Hodge D, Razzook C, Sarhan J, Jones YL, Whittaker GC, Boelte KC, Lyakh L, Cardone M, O'Connor GM, Tan C, Li H, Anderson SK, Jones SA, Zhang W, Taylor PR, Trinchieri G, McVicar DW. Orr SJ, et al. Among authors: jones gw, jones yl, jones sa. PLoS Pathog. 2013 May;9(5):e1003357. doi: 10.1371/journal.ppat.1003357. Epub 2013 May 9. PLoS Pathog. 2013. PMID: 23675302 Free PMC article.
310 results