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Tackling gaps in developing life-changing treatments for dementia.
Mauricio R, Benn C, Davis J, Dawson G, Dawson LA, Evans A, Fox N, Gallacher J, Hutton M, Isaac J, Jones DNC, Jones L, Lalli G, Libri V, Lovestone S, Moody C, Noble W, Perry H, Pickett J, Reynolds D, Ritchie C, Rohrer JD, Routledge C, Rowe J, Snyder H, Spires-Jones T, Swartz J, Truyen L, Whiting P; Therapeutics for Dementia Consortium. Mauricio R, et al. Among authors: jones dnc. Alzheimers Dement (N Y). 2019 Jun 24;5:241-253. doi: 10.1016/j.trci.2019.05.001. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31297438 Free PMC article. Review.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium; Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Mancuso R, et al. Among authors: jones dnc. Brain. 2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. Brain. 2019. PMID: 31504240 Free PMC article.
Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders.
Bhattacharya A, Jones DNC. Bhattacharya A, et al. Among authors: jones dnc. Psychoneuroendocrinology. 2018 Dec;98:95-100. doi: 10.1016/j.psyneuen.2018.08.015. Epub 2018 Aug 14. Psychoneuroendocrinology. 2018. PMID: 30121550 Review.
Treatment-resistant depression and peripheral C-reactive protein.
Chamberlain SR, Cavanagh J, de Boer P, Mondelli V, Jones DNC, Drevets WC, Cowen PJ, Harrison NA, Pointon L, Pariante CM, Bullmore ET. Chamberlain SR, et al. Among authors: jones dnc. Br J Psychiatry. 2019 Jan;214(1):11-19. doi: 10.1192/bjp.2018.66. Epub 2018 May 16. Br J Psychiatry. 2019. PMID: 29764522 Free PMC article.
Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator.
Ward SE, Beswick P, Calcinaghi N, Dawson LA, Gartlon J, Graziani F, Jones DN, Lacroix L, Selina Mok MH, Oliosi B, Pardoe J, Starr K, Woolley ML, Harries MH. Ward SE, et al. Br J Pharmacol. 2017 Mar;174(5):370-385. doi: 10.1111/bph.13696. Epub 2017 Jan 31. Br J Pharmacol. 2017. PMID: 28009436 Free PMC article.
In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics.
Dawson LA, Langmead CJ, Dada A, Watson JM, Wu Z, de la Flor R, Jones GA, Cluderay JE, Southam E, Murkitt GS, Hill MD, Jones DN, Davies CH, Hagan JJ, Smith PW. Dawson LA, et al. Eur J Pharmacol. 2010 Feb 10;627(1-3):106-14. doi: 10.1016/j.ejphar.2009.10.054. Epub 2009 Oct 30. Eur J Pharmacol. 2010. PMID: 19879867
46 results