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Targeting the epigenetic regulation of antitumour immunity.
Hogg SJ, Beavis PA, Dawson MA, Johnstone RW. Hogg SJ, et al. Among authors: johnstone rw. Nat Rev Drug Discov. 2020 Nov;19(11):776-800. doi: 10.1038/s41573-020-0077-5. Epub 2020 Sep 14. Nat Rev Drug Discov. 2020. PMID: 32929243 Review.
Anticancer activities of histone deacetylase inhibitors.
Bolden JE, Peart MJ, Johnstone RW. Bolden JE, et al. Among authors: johnstone rw. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. doi: 10.1038/nrd2133. Nat Rev Drug Discov. 2006. PMID: 16955068 Review.
Epigenetics in cancer: targeting chromatin modifications.
Ellis L, Atadja PW, Johnstone RW. Ellis L, et al. Among authors: johnstone rw. Mol Cancer Ther. 2009 Jun;8(6):1409-20. doi: 10.1158/1535-7163.MCT-08-0860. Epub 2009 Jun 9. Mol Cancer Ther. 2009. PMID: 19509247 Review.
Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.
Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW. Waibel M, et al. Among authors: johnstone rw. Cell Rep. 2013 Nov 27;5(4):1047-59. doi: 10.1016/j.celrep.2013.10.038. Epub 2013 Nov 21. Cell Rep. 2013. PMID: 24268771 Free PMC article.
The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound.
Shortt J, Hsu AK, Martin BP, Doggett K, Matthews GM, Doyle MA, Ellul J, Jockel TE, Andrews DM, Hogg SJ, Reitsma A, Faulkner D, Bergsagel PL, Chesi M, Heath JK, Denny WA, Thompson PE, Neeson PJ, Ritchie DS, McArthur GA, Johnstone RW. Shortt J, et al. Among authors: johnstone rw. Cell Rep. 2014 May 22;7(4):1009-19. doi: 10.1016/j.celrep.2014.04.008. Epub 2014 May 9. Cell Rep. 2014. PMID: 24813887 Free article.
CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.
Gregory GP, Hogg SJ, Kats LM, Vidacs E, Baker AJ, Gilan O, Lefebure M, Martin BP, Dawson MA, Johnstone RW, Shortt J. Gregory GP, et al. Among authors: johnstone rw. Leukemia. 2015 Jun;29(6):1437-41. doi: 10.1038/leu.2015.10. Epub 2014 Jan 12. Leukemia. 2015. PMID: 25578475 Free PMC article. No abstract available.
286 results