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Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Baell JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, Bergamasco MI, May RE, Davey BK, Morgan KJ, Sealey AJ, Wang B, Zamudio N, Wilcox S, Garnham AL, Sheikh BN, Aubrey BJ, Doggett K, Chung MC, de Silva M, Bentley J, Pilling P, Hattarki M, Dolezal O, Dennis ML, Falk H, Ren B, Charman SA, White KL, Rautela J, Newbold A, Hawkins ED, Johnstone RW, Huntington ND, Peat TS, Heath JK, Strasser A, Parker MW, Smyth GK, Street IP, Monahan BJ, Voss AK, Thomas T. Baell JB, et al. Among authors: johnstone rw. Nature. 2018 Aug;560(7717):253-257. doi: 10.1038/s41586-018-0387-5. Epub 2018 Aug 1. Nature. 2018. PMID: 30069049
A central role for Bid in granzyme B-induced apoptosis.
Waterhouse NJ, Sedelies KA, Browne KA, Wowk ME, Newbold A, Sutton VR, Clarke CJ, Oliaro J, Lindemann RK, Bird PI, Johnstone RW, Trapani JA. Waterhouse NJ, et al. Among authors: johnstone rw. J Biol Chem. 2005 Feb 11;280(6):4476-82. doi: 10.1074/jbc.M410985200. Epub 2004 Dec 1. J Biol Chem. 2005. PMID: 15574417 Free article.
Anticancer activities of histone deacetylase inhibitors.
Bolden JE, Peart MJ, Johnstone RW. Bolden JE, et al. Among authors: johnstone rw. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. doi: 10.1038/nrd2133. Nat Rev Drug Discov. 2006. PMID: 16955068 Review.
Histone deacetylase inhibitors in cancer therapy.
Rasheed WK, Johnstone RW, Prince HM. Rasheed WK, et al. Among authors: johnstone rw. Expert Opin Investig Drugs. 2007 May;16(5):659-78. doi: 10.1517/13543784.16.5.659. Expert Opin Investig Drugs. 2007. PMID: 17461739 Review.
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma.
Lindemann RK, Newbold A, Whitecross KF, Cluse LA, Frew AJ, Ellis L, Williams S, Wiegmans AP, Dear AE, Scott CL, Pellegrini M, Wei A, Richon VM, Marks PA, Lowe SW, Smyth MJ, Johnstone RW. Lindemann RK, et al. Among authors: johnstone rw. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8071-6. doi: 10.1073/pnas.0702294104. Epub 2007 Apr 30. Proc Natl Acad Sci U S A. 2007. PMID: 17470784 Free PMC article.
286 results