Johnson ME - Search Results

1

Identification of Small Molecule Inhibitors against Staphylococcus aureus Dihydroorotase via HTS.

Rice AJ, Pesavento RP, Ren J, Youn I, Kwon Y, Ellepola K, Che CT, Johnson ME, Lee H. Rice AJ, et al. Among authors: johnson me. Int J Mol Sci. 2021 Sep 15;22(18):9984. doi: 10.3390/ijms22189984. Int J Mol Sci. 2021. PMID: 34576147 Free PMC article.

2

Structure of dihydroorotase from Bacillus anthracis at 2.6 Å resolution.

Mehboob S, Mulhearn DC, Truong K, Johnson ME, Santarsiero BD. Mehboob S, et al. Among authors: johnson me. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1432-5. doi: 10.1107/S1744309110037085. Epub 2010 Oct 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 21045288 Free PMC article.

3

Reducing agents affect inhibitory activities of compounds: results from multiple drug targets.

Lee H, Torres J, Truong L, Chaudhuri R, Mittal A, Johnson ME. Lee H, et al. Among authors: johnson me. Anal Biochem. 2012 Apr 1;423(1):46-53. doi: 10.1016/j.ab.2012.01.006. Epub 2012 Jan 18. Anal Biochem. 2012. PMID: 22310499 Free PMC article.

4

Identification of non-macrocyclic small molecule inhibitors against the NS3/4A serine protease of hepatitis C virus through in silico screening.

Chaudhuri R, Lee H, Truong L, Torres J, Patel K, Johnson ME. Chaudhuri R, et al. Among authors: johnson me. J Chem Inf Model. 2012 Aug 27;52(8):2245-56. doi: 10.1021/ci300177p. Epub 2012 Jul 20. J Chem Inf Model. 2012. PMID: 22697413

5

High-level expression, purification, and characterization of Staphylococcus aureus dihydroorotase (PyrC) as a cleavable His-SUMO fusion.

Truong L, Hevener KE, Rice AJ, Patel K, Johnson ME, Lee H. Truong L, et al. Among authors: johnson me. Protein Expr Purif. 2013 Mar;88(1):98-106. doi: 10.1016/j.pep.2012.11.018. Epub 2012 Dec 13. Protein Expr Purif. 2013. PMID: 23246866 Free PMC article.

6

Fragment-based drug discovery using a multidomain, parallel MD-MM/PBSA screening protocol.

Zhu T, Lee H, Lei H, Jones C, Patel K, Johnson ME, Hevener KE. Zhu T, et al. Among authors: johnson me. J Chem Inf Model. 2013 Mar 25;53(3):560-72. doi: 10.1021/ci300502h. Epub 2013 Mar 14. J Chem Inf Model. 2013. PMID: 23432621 Free PMC article.

7

A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups.

Rice AJ, Truong L, Johnson ME, Lee H. Rice AJ, et al. Among authors: johnson me. Anal Biochem. 2013 Oct 1;441(1):87-94. doi: 10.1016/j.ab.2013.05.035. Epub 2013 Jun 13. Anal Biochem. 2013. PMID: 23769705

8

Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.

Lee H, Cao S, Hevener KE, Truong L, Gatuz JL, Patel K, Ghosh AK, Johnson ME. Lee H, et al. Among authors: johnson me. ChemMedChem. 2013 Aug;8(8):1361-72. doi: 10.1002/cmdc.201300134. Epub 2013 Jun 20. ChemMedChem. 2013. PMID: 23788528 Free PMC article.

9

High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes.

Lee H, Zhu T, Patel K, Zhang YY, Truong L, Hevener KE, Gatuz JL, Subramanya G, Jeong HY, Uprichard SL, Johnson ME. Lee H, et al. Among authors: johnson me. PLoS One. 2013 Oct 9;8(10):e75144. doi: 10.1371/journal.pone.0075144. eCollection 2013. PLoS One. 2013. PMID: 24130685 Free PMC article.

10

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.

Lee H, Mittal A, Patel K, Gatuz JL, Truong L, Torres J, Mulhearn DC, Johnson ME. Lee H, et al. Among authors: johnson me. Bioorg Med Chem. 2014 Jan 1;22(1):167-77. doi: 10.1016/j.bmc.2013.11.041. Epub 2013 Dec 1. Bioorg Med Chem. 2014. PMID: 24332657 Free PMC article.

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