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Page 1
Cryptic Epoxytiglianes from the Kernels of the Blushwood Tree (Fontainea picrosperma).
Chianese G, Amin HIM, Maioli C, Reddell P, Parsons P, Cullen J, Johns J, Handoko H, Boyle G, Appendino G, Taglialatela-Scafati O, Gaeta S. Chianese G, et al. Among authors: johns j. J Nat Prod. 2022 Aug 26;85(8):1959-1966. doi: 10.1021/acs.jnatprod.2c00226. Epub 2022 Aug 16. J Nat Prod. 2022. PMID: 35973043 Free PMC article. Review.
[4+2] cycloaddition reactions between 1,8-disubstituted cyclooctatetraenes and diazo dienophiles: stereoelectronic effects, anticancer properties and application to the synthesis of 7,8-substituted bicyclo[4.2.0]octa-2,4-dienes.
Grange RL, Gallen MJ, Schill H, Johns JP, Dong L, Parsons PG, Reddell PW, Gordon VA, Bernhardt PV, Williams CM. Grange RL, et al. Among authors: johns jp. Chemistry. 2010 Aug 2;16(29):8894-903. doi: 10.1002/chem.200903454. Chemistry. 2010. PMID: 20572168
Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes.
Cullen JK, Boyle GM, Yap PY, Elmlinger S, Simmons JL, Broit N, Johns J, Ferguson B, Maslovskaya LA, Savchenko AI, Mirzayans PM, Porzelle A, Bernhardt PV, Gordon VA, Reddell PW, Pagani A, Appendino G, Parsons PG, Williams CM. Cullen JK, et al. Among authors: johns j. Sci Rep. 2021 Jan 8;11(1):207. doi: 10.1038/s41598-020-80397-9. Sci Rep. 2021. PMID: 33420238 Free PMC article.
Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds.
Powell LC, Cullen JK, Boyle GM, De Ridder T, Yap PY, Xue W, Pierce CJ, Pritchard MF, Menzies GE, Abdulkarim M, Adams JYM, Stokniene J, Francis LW, Gumbleton M, Johns J, Hill KE, Jones AV, Parsons PG, Reddell P, Thomas DW. Powell LC, et al. Among authors: johns j. Sci Transl Med. 2022 Sep 14;14(662):eabn3758. doi: 10.1126/scitranslmed.abn3758. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103515
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade.
Cullen JK, Yap PY, Ferguson B, Bruce ZC, Koyama M, Handoko H, Hendrawan K, Simmons JL, Brooks KM, Johns J, Wilson ES, de Souza MMA, Broit N, Stewart P, Shelley D, McMahon T, Ogbourne SM, Nguyen TH, Lim YC, Pagani A, Appendino G, Gordon VA, Reddell PW, Boyle GM, Parsons PG. Cullen JK, et al. Among authors: johns j. J Immunother Cancer. 2024 Apr 24;12(4):e006602. doi: 10.1136/jitc-2022-006602. J Immunother Cancer. 2024. PMID: 38658031 Free PMC article.
509 results