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Page 1
Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk.
Feaver RE, Bowers MS, Cole BK, Hoang S, Lawson MJ, Taylor J, LaMoreaux BD, Zhao L, Henke BR, Johns BA, Nyborg AC, Wamhoff BR, Figler RA. Feaver RE, et al. Among authors: johns ba. PLoS One. 2023 Sep 8;18(9):e0291330. doi: 10.1371/journal.pone.0291330. eCollection 2023. PLoS One. 2023. PMID: 37682977 Free PMC article. Clinical Trial.
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.
Armstrong AJ, Henke BR, Collado MS, Taylor JM, Pourtaheri TD, Dillberger JE, Roper TD, Wamhoff BR, Olson MW, Figler RA, Hoang SA, Reardon JE, Johns BA. Armstrong AJ, et al. Among authors: johns ba. J Med Chem. 2021 Apr 22;64(8):5037-5048. doi: 10.1021/acs.jmedchem.1c00124. Epub 2021 Apr 13. J Med Chem. 2021. PMID: 33848153 Free article.
A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.
Armstrong AJ, Collado MS, Henke BR, Olson MW, Hoang SA, Hamilton CA, Pourtaheri TD, Chapman KA, Summar MM, Johns BA, Wamhoff BR, Reardon JE, Figler RA. Armstrong AJ, et al. Among authors: johns ba. Mol Genet Metab. 2021 May;133(1):71-82. doi: 10.1016/j.ymgme.2021.03.001. Epub 2021 Mar 10. Mol Genet Metab. 2021. PMID: 33741272 Free PMC article.
A Phase 1 Study to Assess the Relative Bioavailability, Food Effect, and Safety of a Tablet Formulation of GSK2838232, a Novel HIV Maturation Inhibitor in Healthy Participants After Single and Repeated Doses.
Johnson M, Jewell RC, Gan J, Dumont E, Burns O, Johns BA. Johnson M, et al. Among authors: johns ba. Clin Pharmacol Drug Dev. 2020 Nov;9(8):972-977. doi: 10.1002/cpdd.820. Epub 2020 Jun 18. Clin Pharmacol Drug Dev. 2020. PMID: 32558338 Clinical Trial.
A Phase IIa Study Evaluating Safety, Pharmacokinetics, and Antiviral Activity of GSK2838232, a Novel, Second-generation Maturation Inhibitor, in Participants With Human Immunodeficiency Virus Type 1 Infection.
DeJesus E, Harward S, Jewell RC, Johnson M, Dumont E, Wilches V, Halliday F, Talarico CL, Jeffrey J, Gan J, Xu J, Felizarta F, Scribner A, Ramgopal M, Benson P, Johns BA. DeJesus E, et al. Among authors: johns ba. Clin Infect Dis. 2020 Aug 22;71(5):1255-1262. doi: 10.1093/cid/ciz938. Clin Infect Dis. 2020. PMID: 31769793 Clinical Trial.
The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects.
Johnson M, Jewell RC, Peppercorn A, Gould E, Xu J, Lou Y, Davies M, Baldwin S, Tenorio AR, Burke M, Jeffrey J, Johns BA. Johnson M, et al. Among authors: johns ba. Pharmacol Res Perspect. 2018 Jun 5;6(4):e00408. doi: 10.1002/prp2.408. eCollection 2018 Jul. Pharmacol Res Perspect. 2018. PMID: 29930812 Free PMC article. Clinical Trial.
Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.
Yoshinaga T, Kobayashi M, Seki T, Miki S, Wakasa-Morimoto C, Suyama-Kagitani A, Kawauchi-Miki S, Taishi T, Kawasuji T, Johns BA, Underwood MR, Garvey EP, Sato A, Fujiwara T. Yoshinaga T, et al. Among authors: johns ba. Antimicrob Agents Chemother. 2015 Jan;59(1):397-406. doi: 10.1128/AAC.03909-14. Epub 2014 Nov 3. Antimicrob Agents Chemother. 2015. PMID: 25367908 Free PMC article.
Synthesis and Biological Evaluation of Macrocyclized Betulin Derivatives as a Novel Class of Anti-HIV-1 Maturation Inhibitors.
Tang J, Jones SA, Jeffery JL, Miranda SR, Galardi CM, Irlbeck DM, Brown KW, McDanal CB, Han N, Gao D, Wu Y, Shen B, Liu C, Xi C, Yang H, Li R, Yu Y, Sun Y, Jin Z, Wang E, Johns BA. Tang J, et al. Among authors: johns ba. Open Med Chem J. 2014 Sep 3;8:23-7. doi: 10.2174/1874104501408010023. eCollection 2014. Open Med Chem J. 2014. PMID: 25250097 Free PMC article.
51 results