John AE - Search Results

1

Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling.

Ramis J, Middlewick R, Pappalardo F, Cairns JT, Stewart ID, John AE, Naveed SU, Krishnan R, Miller S, Shaw DE, Brightling CE, Buttery L, Rose F, Jenkins G, Johnson SR, Tatler AL. Ramis J, et al. Among authors: john ae. Eur Respir J. 2022 Jul 7;60(1):2004361. doi: 10.1183/13993003.04361-2020. Print 2022 Jul. Eur Respir J. 2022. PMID: 34996828 Free PMC article.

2

Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter.

John AE, Zhu YM, Brightling CE, Pang L, Knox AJ. John AE, et al. J Immunol. 2009 Oct 1;183(7):4682-92. doi: 10.4049/jimmunol.0803832. Epub 2009 Sep 4. J Immunol. 2009. PMID: 19734226 Free PMC article.

3

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.

Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G. Tatler AL, et al. Among authors: john ae. J Immunol. 2011 Dec 1;187(11):6094-107. doi: 10.4049/jimmunol.1003507. Epub 2011 Oct 24. J Immunol. 2011. PMID: 22025551 Free PMC article.

4

Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.

Clifford RL, John AE, Brightling CE, Knox AJ. Clifford RL, et al. Among authors: john ae. J Immunol. 2012 Jul 15;189(2):819-31. doi: 10.4049/jimmunol.1103641. Epub 2012 Jun 11. J Immunol. 2012. PMID: 22689881 Free PMC article.

5

Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.

John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, Ludbrook S, Blanchard AD, Perkins AC, Jenkins RG, Marshall JF. John AE, et al. J Nucl Med. 2013 Dec;54(12):2146-52. doi: 10.2967/jnumed.113.120592. Epub 2013 Oct 28. J Nucl Med. 2013. PMID: 24167080 Free article.

6

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.

Clifford RL, Patel JK, John AE, Tatler AL, Mazengarb L, Brightling CE, Knox AJ. Clifford RL, et al. Among authors: john ae. Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L962-72. doi: 10.1152/ajplung.00021.2015. Epub 2015 Feb 20. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25713319 Free PMC article.

7

Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.

Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters PJ, Wallace W, Alberti S, Nordheim A, Jenkins G. Tatler AL, et al. Among authors: john ae. J Biol Chem. 2016 Apr 29;291(18):9540-53. doi: 10.1074/jbc.M115.692368. Epub 2016 Feb 9. J Biol Chem. 2016. PMID: 26861876 Free PMC article.

8

Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis.

Habgood AN, Tatler AL, Porte J, Wahl SM, Laurent GJ, John AE, Johnson SR, Jenkins G. Habgood AN, et al. Among authors: john ae. Lab Invest. 2016 Jun;96(6):623-31. doi: 10.1038/labinvest.2016.40. Epub 2016 Mar 14. Lab Invest. 2016. PMID: 26974397 Free PMC article.

9

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.

Tatler AL, Goodwin AT, Gbolahan O, Saini G, Porte J, John AE, Clifford RL, Violette SM, Weinreb PH, Parfrey H, Wolters PJ, Gauldie J, Kolb M, Jenkins G. Tatler AL, et al. Among authors: john ae. PLoS One. 2016 Aug 5;11(8):e0158047. doi: 10.1371/journal.pone.0158047. eCollection 2016. PLoS One. 2016. PMID: 27494713 Free PMC article.

10

Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.

John AE, Wilson MR, Habgood A, Porte J, Tatler AL, Stavrou A, Miele G, Jolly L, Knox AJ, Takata M, Offermanns S, Jenkins RG. John AE, et al. Sci Signal. 2016 Oct 25;9(451):ra104. doi: 10.1126/scisignal.aad5568. Sci Signal. 2016. PMID: 27811142 Free article.

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