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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. Ryan TAJ, et al. Among authors: johansen md. Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1. Nat Commun. 2023. PMID: 37316487 Free PMC article.
The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders.
Chong WC, Shastri MD, Peterson GM, Patel RP, Pathinayake PS, Dua K, Hansbro NG, Hsu AC, Wark PA, Shukla SD, Johansen MD, Schroder K, Hansbro PM. Chong WC, et al. Among authors: johansen md. Clin Transl Immunology. 2021 Feb 11;10(2):e1247. doi: 10.1002/cti2.1247. eCollection 2021. Clin Transl Immunology. 2021. PMID: 33614031 Free PMC article. Review.
Clinical features and mechanistic insights into drug repurposing for combating COVID-19.
Asrani P, Tiwari K, Eapen MS, McAlinden KD, Haug G, Johansen MD, Hansbro PM, Flanagan KL, Hassan MI, Sohal SS. Asrani P, et al. Among authors: johansen md. Int J Biochem Cell Biol. 2022 Jan;142:106114. doi: 10.1016/j.biocel.2021.106114. Epub 2021 Nov 5. Int J Biochem Cell Biol. 2022. PMID: 34748991 Free PMC article. Review.
A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection.
Counoupas C, Johansen MD, Stella AO, Nguyen DH, Ferguson AL, Aggarwal A, Bhattacharyya ND, Grey A, Hutchings O, Patel K, Siddiquee R, Stewart EL, Feng CG, Hansbro NG, Palendira U, Steain MC, Saunders BM, Low JKK, Mackay JP, Kelleher AD, Britton WJ, Turville SG, Hansbro PM, Triccas JA. Counoupas C, et al. Among authors: johansen md. NPJ Vaccines. 2021 Nov 30;6(1):143. doi: 10.1038/s41541-021-00406-4. NPJ Vaccines. 2021. PMID: 34848711 Free PMC article.
Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish.
Kam JY, Hortle E, Krogman E, Warner SE, Wright K, Luo K, Cheng T, Manuneedhi Cholan P, Kikuchi K, Triccas JA, Britton WJ, Johansen MD, Kremer L, Oehlers SH. Kam JY, et al. Among authors: johansen md. Nat Commun. 2022 Feb 17;13(1):952. doi: 10.1038/s41467-022-28638-5. Nat Commun. 2022. PMID: 35177649 Free PMC article.
Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing.
Johansen MD, Mahbub RM, Idrees S, Nguyen DH, Miemczyk S, Pathinayake P, Nichol K, Hansbro NG, Gearing LJ, Hertzog PJ, Gallego-Ortega D, Britton WJ, Saunders BM, Wark PA, Faiz A, Hansbro PM. Johansen MD, et al. Am J Respir Crit Care Med. 2022 Sep 15;206(6):712-729. doi: 10.1164/rccm.202108-1901OC. Am J Respir Crit Care Med. 2022. PMID: 35549656 Free PMC article.
Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients.
Rouet R, Henry JY, Johansen MD, Sobti M, Balachandran H, Langley DB, Walker GJ, Lenthall H, Jackson J, Ubiparipovic S, Mazigi O, Schofield P, Burnett DL, Brown SHJ, Martinello M, Hudson B, Gilroy N, Post JJ, Kelleher A, Jäck HM, Goodnow CC, Turville SG, Rawlinson WD, Bull RA, Stewart AG, Hansbro PM, Christ D. Rouet R, et al. Among authors: johansen md. Nat Commun. 2023 Feb 8;14(1):687. doi: 10.1038/s41467-023-36295-5. Nat Commun. 2023. PMID: 36755042 Free PMC article.
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.
Scaramuzzo G, Nucera F, Asmundo A, Messina R, Mari M, Montanaro F, Johansen MD, Monaco F, Fadda G, Tuccari G, Hansbro NG, Hansbro PM, Hansel TT, Adcock IM, David A, Kirkham P, Caramori G, Volta CA, Spadaro S. Scaramuzzo G, et al. Among authors: johansen md. J Inflamm (Lond). 2023 Mar 20;20(1):11. doi: 10.1186/s12950-023-00333-2. J Inflamm (Lond). 2023. PMID: 36941580 Free PMC article. Review.
69 results