Joerger AC - Search Results

1

Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells.

Luparello C, Cruciata I, Joerger AC, Ocasio CA, Jones R, Tareque RK, Bagley MC, Spencer J, Walker M, Austin C, Ferrara T, D Oca P, Bellina R, Branni R, Caradonna F. Luparello C, et al. Among authors: joerger ac. Int J Mol Sci. 2021 Mar 26;22(7):3410. doi: 10.3390/ijms22073410. Int J Mol Sci. 2021. PMID: 33810274 Free PMC article.

2

Small molecule induced reactivation of mutant p53 in cancer cells.

Liu X, Wilcken R, Joerger AC, Chuckowree IS, Amin J, Spencer J, Fersht AR. Liu X, et al. Among authors: joerger ac. Nucleic Acids Res. 2013 Jul;41(12):6034-44. doi: 10.1093/nar/gkt305. Epub 2013 Apr 29. Nucleic Acids Res. 2013. PMID: 23630318 Free PMC article.

3

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

Joerger AC, Bauer MR, Wilcken R, Baud MGJ, Harbrecht H, Exner TE, Boeckler FM, Spencer J, Fersht AR. Joerger AC, et al. Structure. 2015 Dec 1;23(12):2246-2255. doi: 10.1016/j.str.2015.10.016. Structure. 2015. PMID: 26636255 Free PMC article.

4

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs.

Bauer MR, Jones RN, Baud MG, Wilcken R, Boeckler FM, Fersht AR, Joerger AC, Spencer J. Bauer MR, et al. Among authors: joerger ac. ACS Chem Biol. 2016 Aug 19;11(8):2265-74. doi: 10.1021/acschembio.6b00315. Epub 2016 Jun 21. ACS Chem Biol. 2016. PMID: 27267810 Free PMC article.

5

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

Bauer MR, Jones RN, Tareque RK, Springett B, Dingler FA, Verduci L, Patel KJ, Fersht AR, Joerger AC, Spencer J. Bauer MR, et al. Among authors: joerger ac. Future Med Chem. 2019 Oct;11(19):2491-2504. doi: 10.4155/fmc-2019-0181. Future Med Chem. 2019. PMID: 31633398 Free PMC article.

6

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.

Bauer MR, Krämer A, Settanni G, Jones RN, Ni X, Khan Tareque R, Fersht AR, Spencer J, Joerger AC. Bauer MR, et al. Among authors: joerger ac. ACS Chem Biol. 2020 Mar 20;15(3):657-668. doi: 10.1021/acschembio.9b00748. Epub 2020 Feb 21. ACS Chem Biol. 2020. PMID: 31990523 Free PMC article.

7

Selective targeting of the αC and DFG-out pocket in p38 MAPK.

Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S. Röhm S, et al. Among authors: joerger ac. Eur J Med Chem. 2020 Dec 15;208:112721. doi: 10.1016/j.ejmech.2020.112721. Epub 2020 Aug 20. Eur J Med Chem. 2020. PMID: 33035818

8

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.

Bauer MR, Joerger AC, Fersht AR. Bauer MR, et al. Among authors: joerger ac. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5271-80. doi: 10.1073/pnas.1610421113. Epub 2016 Aug 22. Proc Natl Acad Sci U S A. 2016. PMID: 27551077 Free PMC article.

9

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.

Baud MGJ, Bauer MR, Verduci L, Dingler FA, Patel KJ, Horil Roy D, Joerger AC, Fersht AR. Baud MGJ, et al. Among authors: joerger ac. Eur J Med Chem. 2018 May 25;152:101-114. doi: 10.1016/j.ejmech.2018.04.035. Epub 2018 Apr 21. Eur J Med Chem. 2018. PMID: 29702446 Free PMC article.

10

Extending the Code of Sequence Readout by Gene Regulatory Proteins: The Role of Hoogsteen Base Pairing in p53-DNA Recognition.

Joerger AC. Joerger AC. Structure. 2018 Sep 4;26(9):1163-1165. doi: 10.1016/j.str.2018.08.008. Structure. 2018. PMID: 30184478 Free article.

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