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Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
Choules MP, Wolf NM, Lee H, Anderson JR, Grzelak EM, Wang Y, Ma R, Gao W, McAlpine JB, Jin YY, Cheng J, Lee H, Suh JW, Duc NM, Paik S, Choe JH, Jo EK, Chang CL, Lee JS, Jaki BU, Pauli GF, Franzblau SG, Cho S. Choules MP, et al. Among authors: jin yy. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02204-18. doi: 10.1128/AAC.02204-18. Print 2019 Mar. Antimicrob Agents Chemother. 2019. PMID: 30602512 Free PMC article.
Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502.
Zhou B, Shetye G, Yu Y, Santarsiero BD, Klein LL, Abad-Zapatero C, Wolf NM, Cheng J, Jin Y, Lee H, Suh JW, Lee H, Bisson J, McAlpine JB, Chen SN, Cho SH, Franzblau SG, Pauli GF. Zhou B, et al. J Nat Prod. 2020 Mar 27;83(3):657-667. doi: 10.1021/acs.jnatprod.9b01095. Epub 2020 Feb 7. J Nat Prod. 2020. PMID: 32031795 Free PMC article.
The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.
Gao W, Kim JY, Anderson JR, Akopian T, Hong S, Jin YY, Kandror O, Kim JW, Lee IA, Lee SY, McAlpine JB, Mulugeta S, Sunoqrot S, Wang Y, Yang SH, Yoon TM, Goldberg AL, Pauli GF, Suh JW, Franzblau SG, Cho S. Gao W, et al. Among authors: jin yy. Antimicrob Agents Chemother. 2015 Feb;59(2):880-9. doi: 10.1128/AAC.04054-14. Epub 2014 Nov 24. Antimicrob Agents Chemother. 2015. PMID: 25421483 Free PMC article.
High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads.
Wolf NM, Lee H, Choules MP, Pauli GF, Phansalkar R, Anderson JR, Gao W, Ren J, Santarsiero BD, Lee H, Cheng J, Jin YY, Ho NA, Duc NM, Suh JW, Abad-Zapatero C, Cho S. Wolf NM, et al. Among authors: jin yy. ACS Infect Dis. 2019 Jun 14;5(6):829-840. doi: 10.1021/acsinfecdis.8b00276. Epub 2019 May 3. ACS Infect Dis. 2019. PMID: 30990022 Free PMC article.
Discovery and characterization of the tuberculosis drug lead ecumicin.
Gao W, Kim JY, Chen SN, Cho SH, Choi J, Jaki BU, Jin YY, Lankin DC, Lee JE, Lee SY, McAlpine JB, Napolitano JG, Franzblau SG, Suh JW, Pauli GF. Gao W, et al. Among authors: jin yy. Org Lett. 2014 Dec 5;16(23):6044-7. doi: 10.1021/ol5026603. Epub 2014 Nov 19. Org Lett. 2014. PMID: 25409285 Free PMC article.
Rufomycins or Ilamycins: Naming Clarifications and Definitive Structural Assignments.
Zhou B, Achanta PS, Shetye G, Chen SN, Lee H, Jin YY, Cheng J, Lee MJ, Suh JW, Cho S, Franzblau SG, Pauli GF, McAlpine JB. Zhou B, et al. Among authors: jin yy. J Nat Prod. 2021 Oct 22;84(10):2644-2663. doi: 10.1021/acs.jnatprod.1c00198. Epub 2021 Oct 10. J Nat Prod. 2021. PMID: 34628863 Free PMC article.
Computer-assisted 1 H NMR analysis of the anti-tuberculosis drug lead ecumicin.
Gao W, Napolitano JG, Lankin DC, Kim JY, Jin YY, Lee H, Suh JW, Chen SN, Pauli GF. Gao W, et al. Among authors: jin yy. Magn Reson Chem. 2017 Mar;55(3):239-244. doi: 10.1002/mrc.4425. Epub 2016 Apr 19. Magn Reson Chem. 2017. PMID: 27094011 Free PMC article. No abstract available.
180 results