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Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients.
Afzal S, Gusella M, Vainer B, Vogel UB, Andersen JT, Broedbaek K, Petersen M, Jimenez-Solem E, Bertolaso L, Barile C, Padrini R, Pasini F, Jensen SA, Poulsen HE. Afzal S, et al. Clin Cancer Res. 2011 Jun 1;17(11):3822-9. doi: 10.1158/1078-0432.CCR-11-0304. Epub 2011 Apr 6. Clin Cancer Res. 2011. PMID: 21471424
The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.
Afzal S, Gusella M, Jensen SA, Vainer B, Vogel U, Andersen JT, Brødbæk K, Petersen M, Jimenez-Solem E, Adleff V, Budai B, Hitre E, Láng I, Orosz E, Bertolaso L, Barile C, Padrini R, Kralovánszky J, Pasini F, Poulsen HE. Afzal S, et al. Pharmacogenomics. 2011 Sep;12(9):1257-67. doi: 10.2217/pgs.11.83. Pharmacogenomics. 2011. PMID: 21919605
Effect of the Arg389Gly β₁-adrenoceptor polymorphism on plasma renin activity and heart rate, and the genotype-dependent response to metoprolol treatment.
Petersen M, Andersen JT, Jimenez-Solem E, Broedbaek K, Hjelvang BR, Henriksen T, Frandsen E, Forman JL, Torp-Pedersen C, Køber L, Poulsen HE. Petersen M, et al. Clin Exp Pharmacol Physiol. 2012 Sep;39(9):779-85. doi: 10.1111/j.1440-1681.2012.05736.x. Clin Exp Pharmacol Physiol. 2012. PMID: 22703382 Clinical Trial.
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