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Inflammasome activation: from molecular mechanisms to autoinflammation.
Lara-Reyna S, Caseley EA, Topping J, Rodrigues F, Jimenez Macias J, Lawler SE, McDermott MF. Lara-Reyna S, et al. Among authors: jimenez macias j. Clin Transl Immunology. 2022 Jul 7;11(7):e1404. doi: 10.1002/cti2.1404. eCollection 2022. Clin Transl Immunology. 2022. PMID: 35832835 Free PMC article. Review.
STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models.
Berger G, Knelson EH, Jimenez-Macias JL, Nowicki MO, Han S, Panagioti E, Lizotte PH, Adu-Berchie K, Stafford A, Dimitrakakis N, Zhou L, Chiocca EA, Mooney DJ, Barbie DA, Lawler SE. Berger G, et al. Among authors: jimenez macias jl. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2111003119. doi: 10.1073/pnas.2111003119. Epub 2022 Jul 5. Proc Natl Acad Sci U S A. 2022. PMID: 35787058 Free PMC article.
PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models.
Zdioruk M, Jimenez-Macias JL, Nowicki MO, Manz KE, Pennell KD, Koch MS, Finkelberg T, Wu B, Boucher P, Takeda Y, Li W, Piranlioglu R, Ling AL, Chiocca EA, Lawler SE. Zdioruk M, et al. Among authors: jimenez macias jl. Cell Rep Med. 2023 May 16;4(5):101019. doi: 10.1016/j.xcrm.2023.101019. Epub 2023 Apr 14. Cell Rep Med. 2023. PMID: 37060903 Free PMC article.
Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues.
Ingram N, McVeigh LE, Abou-Saleh RH, Maynard J, Peyman SA, McLaughlan JR, Fairclough M, Marston G, Valleley EMA, Jimenez-Macias JL, Charalambous A, Townley W, Haddrick M, Wierzbicki A, Wright A, Volpato M, Simpson PB, Treanor DE, Thomson NH, Loadman PM, Bushby RJ, Johnson BRG, Jones PF, Evans JA, Freear S, Markham AF, Evans SD, Coletta PL. Ingram N, et al. Among authors: jimenez macias jl. Theranostics. 2020 Sep 1;10(24):10973-10992. doi: 10.7150/thno.49670. eCollection 2020. Theranostics. 2020. PMID: 33042265 Free PMC article.