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Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry.
Ferhati X, Jiménez-Moreno E, Hoyt EA, Salluce G, Cabeza-Cabrerizo M, Navo CD, Compañón I, Akkapeddi P, Matos MJ, Salaverri N, Garrido P, Martínez A, Laserna V, Murray TV, Jiménez-Osés G, Ravn P, Bernardes GJL, Corzana F. Ferhati X, et al. Among authors: jimenez moreno e. J Am Chem Soc. 2022 Mar 30;144(12):5284-5294. doi: 10.1021/jacs.1c07675. Epub 2022 Mar 16. J Am Chem Soc. 2022. PMID: 35293206 Free PMC article.
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
Ferhati X, Salas-Cubero M, Garrido P, García-Sanmartín J, Guerreiro A, Avenoza A, Busto JH, Peregrina JM, Martínez A, Jiménez-Moreno E, Bernardes GJL, Corzana F. Ferhati X, et al. Among authors: jimenez moreno e. Org Lett. 2021 Nov 5;23(21):8580-8584. doi: 10.1021/acs.orglett.1c03299. Epub 2021 Oct 25. Org Lett. 2021. PMID: 34694118 Free PMC article.
Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Macías-León J , Bermejo IA , Asín A , García-García A , Compañón I , Jiménez-Moreno E , Coelho H , Mangini V , Albuquerque IS , Marcelo F , Asensio JL , Bernardes GJL , Joshi HJ , Fiammengo R , Blixt O , Hurtado-Guerrero R , Corzana F . Macías-León J , et al. Among authors: jimenez moreno e. Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140. doi: 10.1039/d0cc06349e. Chem Commun (Camb). 2020. PMID: 33211039
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment.
Bermejo IA, Navo CD, Castro-López J, Guerreiro A, Jiménez-Moreno E, Sánchez Fernández EM, García-Martín F, Hinou H, Nishimura SI, García Fernández JM, Mellet CO, Avenoza A, Busto JH, Bernardes GJL, Hurtado-Guerrero R, Peregrina JM, Corzana F. Bermejo IA, et al. Among authors: jimenez moreno e. Chem Sci. 2020 Mar 27;11(15):3996-4006. doi: 10.1039/c9sc06334j. Chem Sci. 2020. PMID: 34122869 Free PMC article.
36 results