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Recent applications of click chemistry in drug discovery.
Jiang X, Hao X, Jing L, Wu G, Kang D, Liu X, Zhan P. Jiang X, et al. Expert Opin Drug Discov. 2019 Aug;14(8):779-789. doi: 10.1080/17460441.2019.1614910. Epub 2019 May 16. Expert Opin Drug Discov. 2019. PMID: 31094231 Review.
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.
Huang B, Chen W, Zhao T, Li Z, Jiang X, Ginex T, Vílchez D, Luque FJ, Kang D, Gao P, Zhang J, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Huang B, et al. Among authors: jiang x. J Med Chem. 2019 Feb 28;62(4):2083-2098. doi: 10.1021/acs.jmedchem.8b01729. Epub 2019 Feb 20. J Med Chem. 2019. PMID: 30721060
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties.
Jiang X, Huang B, Olotu FA, Li J, Kang D, Wang Z, De Clercq E, Soliman MES, Pannecouque C, Liu X, Zhan P. Jiang X, et al. Eur J Med Chem. 2021 Mar 5;213:113051. doi: 10.1016/j.ejmech.2020.113051. Epub 2020 Nov 27. Eur J Med Chem. 2021. PMID: 33279288
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