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Recent advances in developing small-molecule inhibitors against SARS-CoV-2.
Xiang R, Yu Z, Wang Y, Wang L, Huo S, Li Y, Liang R, Hao Q, Ying T, Gao Y, Yu F, Jiang S. Xiang R, et al. Among authors: jiang s. Acta Pharm Sin B. 2022 Apr;12(4):1591-1623. doi: 10.1016/j.apsb.2021.06.016. Epub 2021 Jul 2. Acta Pharm Sin B. 2022. PMID: 34249607 Free PMC article. Review.
Small molecule fusion inhibitors: design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41.
He XY, Lu L, Qiu J, Zou P, Yu F, Jiang XK, Li L, Jiang S, Liu S, Xie L. He XY, et al. Among authors: jiang s, jiang xk. Bioorg Med Chem. 2013 Dec 1;21(23):7539-48. doi: 10.1016/j.bmc.2013.04.046. Epub 2013 Apr 26. Bioorg Med Chem. 2013. PMID: 23673219
A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines.
Du L, Kou Z, Ma C, Tao X, Wang L, Zhao G, Chen Y, Yu F, Tseng CT, Zhou Y, Jiang S. Du L, et al. Among authors: jiang s. PLoS One. 2013 Dec 4;8(12):e81587. doi: 10.1371/journal.pone.0081587. eCollection 2013. PLoS One. 2013. PMID: 24324708 Free PMC article.
Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.
Wang C, Shi W, Cai L, Lu L, Yu F, Wang Q, Jiang X, Xu X, Wang K, Xu L, Jiang S, Liu K. Wang C, et al. Among authors: jiang s, jiang x. J Antimicrob Chemother. 2014 Jun;69(6):1537-45. doi: 10.1093/jac/dku010. Epub 2014 Feb 4. J Antimicrob Chemother. 2014. PMID: 24500189
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