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Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism.
Yan Y, Niu Z, Sun C, Li P, Shen S, Liu S, Wu Y, Yun C, Jiao T, Jia S, Li Y, Fang ZZ, Zhao L, Wang J, Xie C, Jiang C, Li Y, Feng X, Hu C, Jiang J, Ying H. Yan Y, et al. Among authors: jiang c, jiang j. Nat Commun. 2022 Oct 27;13(1):6408. doi: 10.1038/s41467-022-34258-w. Nat Commun. 2022. PMID: 36302774 Free PMC article.
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C. Sun L, et al. Among authors: jiang c. Nat Med. 2018 Dec;24(12):1919-1929. doi: 10.1038/s41591-018-0222-4. Epub 2018 Nov 5. Nat Med. 2018. PMID: 30397356 Free PMC article.
Estrogen deficiency induces bone loss through the gut microbiota.
Guan Z, Xuanqi Z, Zhu J, Yuan W, Jia J, Zhang C, Sun T, Leng H, Jiang C, Xu Y, Song C. Guan Z, et al. Among authors: jiang c. Pharmacol Res. 2023 Oct;196:106930. doi: 10.1016/j.phrs.2023.106930. Epub 2023 Sep 16. Pharmacol Res. 2023. PMID: 37722518 Free article.
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