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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.
Kim AS, Kafai NM, Winkler ES, Gilliland TC Jr, Cottle EL, Earnest JT, Jethva PN, Kaplonek P, Shah AP, Fong RH, Davidson E, Malonis RJ, Quiroz JA, Williamson LE, Vang L, Mack M, Crowe JE Jr, Doranz BJ, Lai JR, Alter G, Gross ML, Klimstra WB, Fremont DH, Diamond MS. Kim AS, et al. Among authors: jethva pn. Cell. 2021 Aug 19;184(17):4414-4429.e19. doi: 10.1016/j.cell.2021.07.006. Cell. 2021. PMID: 34416146 Free PMC article.
Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses.
VanBlargan LA, Errico JM, Kafai NM, Burgomaster KE, Jethva PN, Broeckel RM, Meade-White K, Nelson CA, Himansu S, Wang D, Handley SA, Gross ML, Best SM, Pierson TC, Fremont DH, Diamond MS. VanBlargan LA, et al. Among authors: jethva pn. J Exp Med. 2021 May 3;218(5):e20210174. doi: 10.1084/jem.20210174. J Exp Med. 2021. PMID: 33831142 Free PMC article.
Isolation of a Potently Neutralizing and Protective Human Monoclonal Antibody Targeting Yellow Fever Virus.
Doyle MP, Genualdi JR, Bailey AL, Kose N, Gainza C, Rodriguez J, Reeder KM, Nelson CA, Jethva PN, Sutton RE, Bombardi RG, Gross ML, Julander JG, Fremont DH, Diamond MS, Crowe JE Jr. Doyle MP, et al. Among authors: jethva pn. mBio. 2022 Jun 28;13(3):e0051222. doi: 10.1128/mbio.00512-22. Epub 2022 Apr 14. mBio. 2022. PMID: 35420472 Free PMC article.
A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection.
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Chong Z, Whitener BM, Shrihari S, Jethva PN, Gross ML, Crowe JE Jr, Whelan SPJ, Diamond MS, Fremont DH. Adams LJ, et al. Among authors: jethva pn. Cell Rep Med. 2023 Dec 19;4(12):101305. doi: 10.1016/j.xcrm.2023.101305. Epub 2023 Nov 30. Cell Rep Med. 2023. PMID: 38039973 Free PMC article.
13 results