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Challenges and opportunities for non-antibody scaffold drugs.
Vazquez-Lombardi R, Phan TG, Zimmermann C, Lowe D, Jermutus L, Christ D. Vazquez-Lombardi R, et al. Among authors: jermutus l. Drug Discov Today. 2015 Oct;20(10):1271-83. doi: 10.1016/j.drudis.2015.09.004. Epub 2015 Sep 7. Drug Discov Today. 2015. PMID: 26360055 Free article. Review.
Aggregation, stability, and formulation of human antibody therapeutics.
Lowe D, Dudgeon K, Rouet R, Schofield P, Jermutus L, Christ D. Lowe D, et al. Among authors: jermutus l. Adv Protein Chem Struct Biol. 2011;84:41-61. doi: 10.1016/B978-0-12-386483-3.00004-5. Adv Protein Chem Struct Biol. 2011. PMID: 21846562 Review.
Expression of high-affinity human antibody fragments in bacteria.
Rouet R, Lowe D, Dudgeon K, Roome B, Schofield P, Langley D, Andrews J, Whitfeld P, Jermutus L, Christ D. Rouet R, et al. Among authors: jermutus l. Nat Protoc. 2012 Feb 2;7(2):364-73. doi: 10.1038/nprot.2011.448. Nat Protoc. 2012. PMID: 22301775
Exploiting protease activation for therapy.
Bleuez C, Koch WF, Urbach C, Hollfelder F, Jermutus L. Bleuez C, et al. Among authors: jermutus l. Drug Discov Today. 2022 Jun;27(6):1743-1754. doi: 10.1016/j.drudis.2022.03.011. Epub 2022 Mar 18. Drug Discov Today. 2022. PMID: 35314338 Free PMC article. Review.
Tailored amino acid diversity for the evolution of antibody affinity.
González-Muñoz A, Bokma E, O'Shea D, Minton K, Strain M, Vousden K, Rossant C, Jermutus L, Minter R. González-Muñoz A, et al. Among authors: jermutus l. MAbs. 2012 Nov-Dec;4(6):664-72. doi: 10.4161/mabs.21728. Epub 2012 Aug 27. MAbs. 2012. PMID: 22926024 Free PMC article.
Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis.
Minter RR, Cohen ES, Wang B, Liang M, Vainshtein I, Rees G, Eghobamien L, Harrison P, Sims DA, Matthews C, Wilkinson T, Monk P, Drinkwater C, Fabri L, Nash A, McCourt M, Jermutus L, Roskos L, Anderson IK, Sleeman MA. Minter RR, et al. Among authors: jermutus l. Br J Pharmacol. 2013 Jan;168(1):200-11. doi: 10.1111/j.1476-5381.2012.02173.x. Br J Pharmacol. 2013. PMID: 22913645 Free PMC article.
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.
Sandercock AM, Rust S, Guillard S, Sachsenmeier KF, Holoweckyj N, Hay C, Flynn M, Huang Q, Yan K, Herpers B, Price LS, Soden J, Freeth J, Jermutus L, Hollingsworth R, Minter R. Sandercock AM, et al. Among authors: jermutus l. Mol Cancer. 2015 Jul 31;14:147. doi: 10.1186/s12943-015-0415-0. Mol Cancer. 2015. PMID: 26227951 Free PMC article.
81 results