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The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.
Dall'Agnese A, Platt JM, Zheng MM, Friesen M, Dall'Agnese G, Blaise AM, Spinelli JB, Henninger JE, Tevonian EN, Hannett NM, Lazaris C, Drescher HK, Bartsch LM, Kilgore HR, Jaenisch R, Griffith LG, Cisse II, Jeppesen JF, Lee TI, Young RA. Dall'Agnese A, et al. Among authors: jeppesen jf. Nat Commun. 2022 Dec 6;13(1):7522. doi: 10.1038/s41467-022-35176-7. Nat Commun. 2022. PMID: 36473871 Free PMC article.
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Ma H, Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R. Ma H, et al. Among authors: jeppesen jf. Cell Stem Cell. 2022 Nov 3;29(11):1611. doi: 10.1016/j.stem.2022.10.003. Cell Stem Cell. 2022. PMID: 36332573 Free PMC article. No abstract available.
The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action.
Møller LLV, Ali MS, Davey J, Raun SH, Andersen NR, Long JZ, Qian H, Jeppesen JF, Henriquez-Olguin C, Frank E, Jensen TE, Højlund K, Wojtaszewski JFP, Nielsen J, Chiu TT, Jedrychowski MP, Gregorevic P, Klip A, Richter EA, Sylow L. Møller LLV, et al. Among authors: jeppesen jf. Proc Natl Acad Sci U S A. 2023 Jul 4;120(27):e2211041120. doi: 10.1073/pnas.2211041120. Epub 2023 Jun 26. Proc Natl Acad Sci U S A. 2023. PMID: 37364105 Free PMC article.
Combining mass spectrometry and machine learning to discover bioactive peptides.
Madsen CT, Refsgaard JC, Teufel FG, Kjærulff SK, Wang Z, Meng G, Jessen C, Heljo P, Jiang Q, Zhao X, Wu B, Zhou X, Tang Y, Jeppesen JF, Kelstrup CD, Buckley ST, Tullin S, Nygaard-Jensen J, Chen X, Zhang F, Olsen JV, Han D, Grønborg M, de Lichtenberg U. Madsen CT, et al. Among authors: jeppesen jf. Nat Commun. 2022 Oct 20;13(1):6235. doi: 10.1038/s41467-022-34031-z. Nat Commun. 2022. PMID: 36266275 Free PMC article.
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R. Ma H, et al. Among authors: jeppesen jf. Cell Stem Cell. 2022 May 5;29(5):795-809.e11. doi: 10.1016/j.stem.2022.03.015. Epub 2022 Apr 21. Cell Stem Cell. 2022. PMID: 35452598 Free PMC article.
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.
Reddy A, Bozi LHM, Yaghi OK, Mills EL, Xiao H, Nicholson HE, Paschini M, Paulo JA, Garrity R, Laznik-Bogoslavski D, Ferreira JCB, Carl CS, Sjøberg KA, Wojtaszewski JFP, Jeppesen JF, Kiens B, Gygi SP, Richter EA, Mathis D, Chouchani ET. Reddy A, et al. Among authors: jeppesen jf. Cell. 2020 Oct 1;183(1):62-75.e17. doi: 10.1016/j.cell.2020.08.039. Epub 2020 Sep 17. Cell. 2020. PMID: 32946811 Free PMC article.
ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2.
Fritzen AM, Domingo-Espín J, Lundsgaard AM, Kleinert M, Israelsen I, Carl CS, Nicolaisen TS, Kjøbsted R, Jeppesen JF, Wojtaszewski JFP, Lagerstedt JO, Kiens B. Fritzen AM, et al. Among authors: jeppesen jf. Mol Metab. 2020 May;35:100949. doi: 10.1016/j.molmet.2020.01.013. Epub 2020 Mar 4. Mol Metab. 2020. PMID: 32244181 Free PMC article.
16 results