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An LKB1-mitochondria axis controls TH17 effector function.
Baixauli F, Piletic K, Puleston DJ, Villa M, Field CS, Flachsmann LJ, Quintana A, Rana N, Edwards-Hicks J, Matsushita M, Stanczak MA, Grzes KM, Kabat AM, Fabri M, Caputa G, Kelly B, Corrado M, Musa Y, Duda KJ, Mittler G, O'Sullivan D, Sesaki H, Jenuwein T, Buescher JM, Pearce EJ, Sanin DE, Pearce EL. Baixauli F, et al. Among authors: jenuwein t. Nature. 2022 Oct;610(7932):555-561. doi: 10.1038/s41586-022-05264-1. Epub 2022 Sep 28. Nature. 2022. PMID: 36171294 Free PMC article.
Acetate Promotes T Cell Effector Function during Glucose Restriction.
Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL. Qiu J, et al. Among authors: jenuwein t. Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022. Cell Rep. 2019. PMID: 31091446 Free PMC article.
m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin.
Duda KJ, Ching RW, Jerabek L, Shukeir N, Erikson G, Engist B, Onishi-Seebacher M, Perrera V, Richter F, Mittler G, Fritz K, Helm M, Knuckles P, Bühler M, Jenuwein T. Duda KJ, et al. Among authors: jenuwein t. Nucleic Acids Res. 2021 Jun 4;49(10):5568-5587. doi: 10.1093/nar/gkab364. Nucleic Acids Res. 2021. PMID: 33999208 Free PMC article.
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization.
Montavon T, Shukeir N, Erikson G, Engist B, Onishi-Seebacher M, Ryan D, Musa Y, Mittler G, Meyer AG, Genoud C, Jenuwein T. Montavon T, et al. Among authors: jenuwein t. Nat Commun. 2021 Jul 16;12(1):4359. doi: 10.1038/s41467-021-24532-8. Nat Commun. 2021. PMID: 34272378 Free PMC article.
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. Ohm JE, et al. Among authors: jenuwein t. Nat Genet. 2007 Feb;39(2):237-42. doi: 10.1038/ng1972. Epub 2007 Jan 9. Nat Genet. 2007. PMID: 17211412 Free PMC article.
Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.
Hiragami-Hamada K, Soeroes S, Nikolov M, Wilkins B, Kreuz S, Chen C, De La Rosa-Velázquez IA, Zenn HM, Kost N, Pohl W, Chernev A, Schwarzer D, Jenuwein T, Lorincz M, Zimmermann B, Walla PJ, Neumann H, Baubec T, Urlaub H, Fischle W. Hiragami-Hamada K, et al. Among authors: jenuwein t. Nat Commun. 2016 Apr 19;7:11310. doi: 10.1038/ncomms11310. Nat Commun. 2016. PMID: 27090491 Free PMC article.
The molecular hallmarks of epigenetic control.
Allis CD, Jenuwein T. Allis CD, et al. Among authors: jenuwein t. Nat Rev Genet. 2016 Aug;17(8):487-500. doi: 10.1038/nrg.2016.59. Epub 2016 Jun 27. Nat Rev Genet. 2016. PMID: 27346641 Review.
130 results