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Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells.
Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi-Seebacher M, Yin N, Martagon-Calderón NA, Potts KS, Klaeylé L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E. Lefkopoulos S, et al. Among authors: jenuwein t. Immunity. 2020 Nov 17;53(5):934-951.e9. doi: 10.1016/j.immuni.2020.10.007. Epub 2020 Nov 6. Immunity. 2020. PMID: 33159854 Free article.
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.
Bulut-Karslioglu A, De La Rosa-Velázquez IA, Ramirez F, Barenboim M, Onishi-Seebacher M, Arand J, Galán C, Winter GE, Engist B, Gerle B, O'Sullivan RJ, Martens JH, Walter J, Manke T, Lachner M, Jenuwein T. Bulut-Karslioglu A, et al. Among authors: jenuwein t. Mol Cell. 2014 Jul 17;55(2):277-90. doi: 10.1016/j.molcel.2014.05.029. Epub 2014 Jun 26. Mol Cell. 2014. PMID: 24981170 Free article.
Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.
Velazquez Camacho O, Galan C, Swist-Rosowska K, Ching R, Gamalinda M, Karabiber F, De La Rosa-Velazquez I, Engist B, Koschorz B, Shukeir N, Onishi-Seebacher M, van de Nobelen S, Jenuwein T. Velazquez Camacho O, et al. Among authors: jenuwein t. Elife. 2017 Aug 1;6:e25293. doi: 10.7554/eLife.25293. Elife. 2017. PMID: 28760199 Free PMC article.
m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin.
Duda KJ, Ching RW, Jerabek L, Shukeir N, Erikson G, Engist B, Onishi-Seebacher M, Perrera V, Richter F, Mittler G, Fritz K, Helm M, Knuckles P, Bühler M, Jenuwein T. Duda KJ, et al. Among authors: jenuwein t. Nucleic Acids Res. 2021 Jun 4;49(10):5568-5587. doi: 10.1093/nar/gkab364. Nucleic Acids Res. 2021. PMID: 33999208 Free PMC article.
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization.
Montavon T, Shukeir N, Erikson G, Engist B, Onishi-Seebacher M, Ryan D, Musa Y, Mittler G, Meyer AG, Genoud C, Jenuwein T. Montavon T, et al. Among authors: jenuwein t. Nat Commun. 2021 Jul 16;12(1):4359. doi: 10.1038/s41467-021-24532-8. Nat Commun. 2021. PMID: 34272378 Free PMC article.
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.
Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl R. Savarese F, et al. Among authors: jenuwein t. Genes Dev. 2009 Nov 15;23(22):2625-38. doi: 10.1101/gad.1815709. Genes Dev. 2009. PMID: 19933152 Free PMC article.
H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction.
Healton SE, Pinto HD, Mishra LN, Hamilton GA, Wheat JC, Swist-Rosowska K, Shukeir N, Dou Y, Steidl U, Jenuwein T, Gamble MJ, Skoultchi AI. Healton SE, et al. Among authors: jenuwein t. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14251-14258. doi: 10.1073/pnas.1920725117. Epub 2020 Jun 8. Proc Natl Acad Sci U S A. 2020. PMID: 32513732 Free PMC article.
130 results