Jensen O - Search Results

1

The mystery of the human proton-organic cation antiporter: One transport protein or many?

Sachkova A, Jensen O, Dücker C, Ansari S, Brockmöller J. Sachkova A, et al. Among authors: jensen o. Pharmacol Ther. 2022 Nov;239:108283. doi: 10.1016/j.pharmthera.2022.108283. Epub 2022 Sep 24. Pharmacol Ther. 2022. PMID: 36162727 Review.

2

OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil.

Matthaei J, Seitz T, Jensen O, Tann A, Prukop T, Tadjerpisheh S, Brockmöller J, Tzvetkov MV. Matthaei J, et al. Among authors: jensen o. Clin Pharmacol Ther. 2019 Jan;105(1):190-200. doi: 10.1002/cpt.1128. Epub 2018 Aug 1. Clin Pharmacol Ther. 2019. PMID: 29882324 Clinical Trial.

3

Variability and Heritability of Thiamine Pharmacokinetics With Focus on OCT1 Effects on Membrane Transport and Pharmacokinetics in Humans.

Jensen O, Matthaei J, Blome F, Schwab M, Tzvetkov MV, Brockmöller J. Jensen O, et al. Clin Pharmacol Ther. 2020 Mar;107(3):628-638. doi: 10.1002/cpt.1666. Epub 2019 Nov 23. Clin Pharmacol Ther. 2020. PMID: 31593619

4

Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A.

Rafehi M, Faltraco F, Matthaei J, Prukop T, Jensen O, Grytzmann A, Blome FG, Berger RG, Krings U, Vormfelde SV, Tzvetkov MV, Brockmöller J. Rafehi M, et al. Among authors: jensen o. Front Pharmacol. 2019 Oct 30;10:1297. doi: 10.3389/fphar.2019.01297. eCollection 2019. Front Pharmacol. 2019. PMID: 31736764 Free PMC article.

5

Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters.

Jensen O, Rafehi M, Tzvetkov MV, Brockmöller J. Jensen O, et al. Biochem Pharmacol. 2020 Jan;171:113731. doi: 10.1016/j.bcp.2019.113731. Epub 2019 Nov 27. Biochem Pharmacol. 2020. PMID: 31783011

6

A double-Flp-in method for stable overexpression of two genes.

Jensen O, Ansari S, Gebauer L, Müller SF, Lowjaga KAAT, Geyer J, Tzvetkov MV, Brockmöller J. Jensen O, et al. Sci Rep. 2020 Aug 20;10(1):14018. doi: 10.1038/s41598-020-71051-5. Sci Rep. 2020. PMID: 32820202 Free PMC article.

7

Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?

Jensen O, Rafehi M, Gebauer L, Brockmöller J. Jensen O, et al. Front Pharmacol. 2021 Jan 20;11:609811. doi: 10.3389/fphar.2020.609811. eCollection 2020. Front Pharmacol. 2021. PMID: 33551812 Free PMC article.

8

Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation.

Jensen O, Brockmöller J, Dücker C. Jensen O, et al. J Med Chem. 2021 Mar 11;64(5):2762-2776. doi: 10.1021/acs.jmedchem.0c02047. Epub 2021 Feb 19. J Med Chem. 2021. PMID: 33606526

9

Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport.

Jensen O, Matthaei J, Klemp HG, Meyer MJ, Brockmöller J, Tzvetkov MV. Jensen O, et al. Front Pharmacol. 2021 May 10;12:674559. doi: 10.3389/fphar.2021.674559. eCollection 2021. Front Pharmacol. 2021. PMID: 34040533 Free PMC article.

10

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.

Matthaei J, Brockmöller J, Steimer W, Pischa K, Leucht S, Kullmann M, Jensen O, Ouethy T, Tzvetkov MV, Rafehi M. Matthaei J, et al. Among authors: jensen o. Front Pharmacol. 2021 May 21;12:688950. doi: 10.3389/fphar.2021.688950. eCollection 2021. Front Pharmacol. 2021. PMID: 34093211 Free PMC article.

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