Jensen KG - Search Results

1

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Among authors: jensen kg. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.

2

Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods.

Jensen KG, Jacobsen AM, Bundgaard C, Nilausen DØ, Thale Z, Chandrasena G, Jørgensen M. Jensen KG, et al. Drug Metab Dispos. 2017 Jan;45(1):68-75. doi: 10.1124/dmd.116.072793. Epub 2016 Oct 13. Drug Metab Dispos. 2017. PMID: 27737930 Clinical Trial.

3

Identification of a new series of non-peptidic NK3 receptor antagonists.

Juhl K, Hansen T, Kehler J, Khanzhin NA, Nørgaard MB, Ruhland T, Larsen DB, Jensen KG, Steiniger-Brach B, Nielsen SM, Simonsen KB. Juhl K, et al. Among authors: jensen kg. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1498-501. doi: 10.1016/j.bmcl.2010.12.135. Epub 2011 Jan 13. Bioorg Med Chem Lett. 2011. PMID: 21292483

4

Synthesis and SAR study of a novel series of dopamine receptor agonists.

Risgaard R, Jensen M, Jørgensen M, Bang-Andersen B, Christoffersen CT, Jensen KG, Kristensen JL, Püschl A. Risgaard R, et al. Among authors: jensen kg, jensen m. Bioorg Med Chem. 2014 Jan 1;22(1):381-92. doi: 10.1016/j.bmc.2013.11.012. Epub 2013 Nov 15. Bioorg Med Chem. 2014. PMID: 24296012

5

Biological conversion of aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug.

Rohde M, M Rk N, Håkansson AE, Jensen KG, Pedersen H, Dige T, J Rgensen EB, Holm R. Rohde M, et al. Among authors: jensen kg. Results Pharma Sci. 2014 May 2;4:19-25. doi: 10.1016/j.rinphs.2014.04.002. eCollection 2014. Results Pharma Sci. 2014. PMID: 25756003 Free PMC article.

6

Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.

Sams AG, Larsen K, Mikkelsen GK, Hentzer M, Christoffersen CT, Jensen KG, Frederiksen K, Bang-Andersen B. Sams AG, et al. Among authors: jensen kg. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5134-40. doi: 10.1016/j.bmcl.2012.05.048. Epub 2012 May 18. Bioorg Med Chem Lett. 2012. PMID: 22677319

7

Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.

Bang-Andersen B, Ruhland T, Jørgensen M, Smith G, Frederiksen K, Jensen KG, Zhong H, Nielsen SM, Hogg S, Mørk A, Stensbøl TB. Bang-Andersen B, et al. Among authors: jensen kg. J Med Chem. 2011 May 12;54(9):3206-21. doi: 10.1021/jm101459g. Epub 2011 Apr 12. J Med Chem. 2011. PMID: 21486038

8

Discovery of novel α₁-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.

Jørgensen M, Jørgensen PN, Christoffersen CT, Jensen KG, Balle T, Bang-Andersen B. Jørgensen M, et al. Among authors: jensen kg. Bioorg Med Chem. 2013 Jan 1;21(1):196-204. doi: 10.1016/j.bmc.2012.10.049. Epub 2012 Nov 15. Bioorg Med Chem. 2013. PMID: 23218776

9

Metabolites of [(14)C]-5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3, 6-tetrahydropyridine in mice, rats, dogs, and humans.

Christensen EB, Andersen JB, Pedersen H, Jensen KG, Dalgaard L. Christensen EB, et al. Among authors: jensen kg. Drug Metab Dispos. 1999 Nov;27(11):1341-9. Drug Metab Dispos. 1999. PMID: 10534320

10

In vitro metabolism of the M1-muscarinic agonist 5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by human hepatic cytochromes P-450 determined at pH 7.4 and 8.5.

Jensen KG, Dalgaard L. Jensen KG, et al. Drug Metab Dispos. 1999 Jan;27(1):125-32. Drug Metab Dispos. 1999. PMID: 9884321

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