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The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones.
PLoS One. 2023 Nov 30;18(11):e0292946. doi: 10.1371/journal.pone.0292946. eCollection 2023.
PLoS One. 2023.
PMID: 38032881
Free PMC article.
Discovery of Antitrypanosomal Indolylacetamides by a Deconstruction-Optimization Strategy Applied to Paullones.
Lindhof JC, Ihnatenko I, Müller MJ, Orban OCF, Ortíz C, Benítez D, Dibello E, Seidl LL, Comini MA, Kunick C.
Lindhof JC, et al.
ChemMedChem. 2023 May 16;18(10):e202300036. doi: 10.1002/cmdc.202300036. Epub 2023 Mar 28.
ChemMedChem. 2023.
PMID: 36847711
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