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Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes.
Ledsgaard L, Wade J, Jenkins TP, Boddum K, Oganesyan I, Harrison JA, Villar P, Leah RA, Zenobi R, Schoffelen S, Voldborg B, Ljungars A, McCafferty J, Lomonte B, Gutiérrez JM, Laustsen AH, Karatt-Vellatt A. Ledsgaard L, et al. Among authors: jenkins tp. Nat Commun. 2023 Feb 8;14(1):682. doi: 10.1038/s41467-023-36393-4. Nat Commun. 2023. PMID: 36755049 Free PMC article.
Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL.
Laprade W, Bartlett KE, Christensen CR, Kazandjian TD, Patel RN, Crittenden E, Dawson CA, Mansourvar M, Wolff DS, Fryer T, Laustsen AH, Casewell NR, Gutiérrez JM, Hall SR, Jenkins TP. Laprade W, et al. Among authors: jenkins tp. Sci Rep. 2023 Dec 8;13(1):21662. doi: 10.1038/s41598-023-49011-6. Sci Rep. 2023. PMID: 38066189 Free PMC article.
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib.
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu LO, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR. Bartlett KE, et al. Among authors: jenkins tp. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2315597121. doi: 10.1073/pnas.2315597121. Epub 2024 Apr 30. Proc Natl Acad Sci U S A. 2024. PMID: 38687786 Free article.
Structural and functional analyses of nematode-derived antimicrobial peptides support the occurrence of direct mechanisms of worm-microbiota interactions.
Rooney J, Rivera-de-Torre E, Li R, Mclean K, Price DRG, Nisbet AJ, Laustsen AH, Jenkins TP, Hofmann A, Bakshi S, Zarkan A, Cantacessi C. Rooney J, et al. Among authors: jenkins tp. Comput Struct Biotechnol J. 2024 Apr 10;23:1522-1533. doi: 10.1016/j.csbj.2024.04.019. eCollection 2024 Dec. Comput Struct Biotechnol J. 2024. PMID: 38633385 Free PMC article.
58 results