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Computationally designed GPCR quaternary structures bias signaling pathway activation.
Paradis JS, Feng X, Murat B, Jefferson RE, Sokrat B, Szpakowska M, Hogue M, Bergkamp ND, Heydenreich FM, Smit MJ, Chevigné A, Bouvier M, Barth P. Paradis JS, et al. Among authors: jefferson re. Nat Commun. 2022 Nov 11;13(1):6826. doi: 10.1038/s41467-022-34382-7. Nat Commun. 2022. PMID: 36369272 Free PMC article.
Membrane proteins can have high kinetic stability.
Jefferson RE, Blois TM, Bowie JU. Jefferson RE, et al. J Am Chem Soc. 2013 Oct 9;135(40):15183-90. doi: 10.1021/ja407232b. Epub 2013 Sep 27. J Am Chem Soc. 2013. PMID: 24032628 Free PMC article.
Short N-terminal sequences package proteins into bacterial microcompartments.
Fan C, Cheng S, Liu Y, Escobar CM, Crowley CS, Jefferson RE, Yeates TO, Bobik TA. Fan C, et al. Among authors: jefferson re. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7509-14. doi: 10.1073/pnas.0913199107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308536 Free PMC article.