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Year Number of Results
2002 1
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2005 3
2006 2
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2009 4
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2011 2
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Page 1
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF. Legru A, et al. Among authors: hernandez jf. Eur J Med Chem. 2024 Apr 5;269:116308. doi: 10.1016/j.ejmech.2024.116308. Epub 2024 Mar 11. Eur J Med Chem. 2024. PMID: 38503166
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor.
Martinez M, Batista FA, Maurel M, Bouillon A, Ortega Varga L, Wehenkel AM, Le Chevalier-Sontag L, Blondel A, Haouz A, Hernandez JF, Alzari PM, Barale JC. Martinez M, et al. Among authors: hernandez jf. Acta Crystallogr D Struct Biol. 2023 Aug 1;79(Pt 8):721-734. doi: 10.1107/S2059798323004710. Epub 2023 Jul 10. Acta Crystallogr D Struct Biol. 2023. PMID: 37428845
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.
Legru A, Verdirosa F, Vo-Hoang Y, Tassone G, Vascon F, Thomas CA, Sannio F, Corsica G, Benvenuti M, Feller G, Coulon R, Marcoccia F, Devente SR, Bouajila E, Piveteau C, Leroux F, Deprez-Poulain R, Deprez B, Licznar-Fajardo P, Crowder MW, Cendron L, Pozzi C, Mangani S, Docquier JD, Hernandez JF, Gavara L. Legru A, et al. Among authors: hernandez jf. J Med Chem. 2022 Dec 22;65(24):16392-16419. doi: 10.1021/acs.jmedchem.2c01257. Epub 2022 Nov 30. J Med Chem. 2022. PMID: 36450011 Free article.
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors.
Gavara L, Verdirosa F, Sevaille L, Legru A, Corsica G, Nauton L, Sandra Mercuri P, Sannio F, De Luca F, Hadjadj M, Cerboni G, Vo Hoang Y, Licznar-Fajardo P, Galleni M, Docquier JD, Hernandez JF. Gavara L, et al. Among authors: hernandez jf. Bioorg Med Chem. 2022 Oct 15;72:116964. doi: 10.1016/j.bmc.2022.116964. Epub 2022 Aug 11. Bioorg Med Chem. 2022. PMID: 36030663 Free article.
1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors.
Verdirosa F, Gavara L, Sevaille L, Tassone G, Corsica G, Legru A, Feller G, Chelini G, Mercuri PS, Tanfoni S, Sannio F, Benvenuti M, Cerboni G, De Luca F, Bouajila E, Vo Hoang Y, Licznar-Fajardo P, Galleni M, Pozzi C, Mangani S, Docquier JD, Hernandez JF. Verdirosa F, et al. Among authors: hernandez jf. ChemMedChem. 2022 Apr 5;17(7):e202100699. doi: 10.1002/cmdc.202100699. Epub 2022 Feb 4. ChemMedChem. 2022. PMID: 35050549
53 results