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Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM. Suofu Y, et al. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5. Proc Natl Acad Sci U S A. 2017. PMID: 28874589 Free PMC article.
Endosomal generation of cAMP in GPCR signaling.
Vilardaga JP, Jean-Alphonse FG, Gardella TJ. Vilardaga JP, et al. Nat Chem Biol. 2014 Sep;10(9):700-6. doi: 10.1038/nchembio.1611. Nat Chem Biol. 2014. PMID: 25271346 Free PMC article. Review.
Design and validation of the first cell-impermeant melatonin receptor agonist.
Gbahou F, Cecon E, Viault G, Gerbier R, Jean-Alphonse F, Karamitri A, Guillaumet G, Delagrange P, Friedlander RM, Vilardaga JP, Suzenet F, Jockers R. Gbahou F, et al. Br J Pharmacol. 2017 Jul;174(14):2409-2421. doi: 10.1111/bph.13856. Epub 2017 Jun 11. Br J Pharmacol. 2017. PMID: 28493341 Free PMC article.
Ca2+ allostery in PTH-receptor signaling.
White AD, Fang F, Jean-Alphonse FG, Clark LJ, An HJ, Liu H, Zhao Y, Reynolds SL, Lee S, Xiao K, Sutkeviciute I, Vilardaga JP. White AD, et al. Among authors: jean alphonse fg. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3294-3299. doi: 10.1073/pnas.1814670116. Epub 2019 Feb 4. Proc Natl Acad Sci U S A. 2019. PMID: 30718391 Free PMC article.
29 results