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Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation.
Clark LJ, Krieger J, White AD, Bondarenko V, Lei S, Fang F, Lee JY, Doruker P, Böttke T, Jean-Alphonse F, Tang P, Gardella TJ, Xiao K, Sutkeviciute I, Coin I, Bahar I, Vilardaga JP. Clark LJ, et al. Nat Chem Biol. 2020 Oct;16(10):1096-1104. doi: 10.1038/s41589-020-0567-0. Epub 2020 Jul 6. Nat Chem Biol. 2020. PMID: 32632293 Free PMC article.
Endosomal generation of cAMP in GPCR signaling.
Vilardaga JP, Jean-Alphonse FG, Gardella TJ. Vilardaga JP, et al. Nat Chem Biol. 2014 Sep;10(9):700-6. doi: 10.1038/nchembio.1611. Nat Chem Biol. 2014. PMID: 25271346 Free PMC article. Review.
Design and validation of the first cell-impermeant melatonin receptor agonist.
Gbahou F, Cecon E, Viault G, Gerbier R, Jean-Alphonse F, Karamitri A, Guillaumet G, Delagrange P, Friedlander RM, Vilardaga JP, Suzenet F, Jockers R. Gbahou F, et al. Br J Pharmacol. 2017 Jul;174(14):2409-2421. doi: 10.1111/bph.13856. Epub 2017 Jun 11. Br J Pharmacol. 2017. PMID: 28493341 Free PMC article.
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM. Suofu Y, et al. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5. Proc Natl Acad Sci U S A. 2017. PMID: 28874589 Free PMC article.
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
Zhang Q, Xiao K, Paredes JM, Mamonova T, Sneddon WB, Liu H, Wang D, Li S, McGarvey JC, Uehling D, Al-Awar R, Joseph B, Jean-Alphonse F, Orte A, Friedman PA. Zhang Q, et al. J Biol Chem. 2019 Mar 22;294(12):4546-4571. doi: 10.1074/jbc.RA119.007421. Epub 2019 Jan 29. J Biol Chem. 2019. PMID: 30696771 Free PMC article.
34 results