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OCT4 interprets and enhances nucleosome flexibility.
MacCarthy CM, Huertas J, Ortmeier C, Vom Bruch H, Tan DS, Reinke D, Sander A, Bergbrede T, Jauch R, Schöler HR, Cojocaru V. MacCarthy CM, et al. Among authors: jauch r. Nucleic Acids Res. 2022 Oct 14;50(18):10311-10327. doi: 10.1093/nar/gkac755. Nucleic Acids Res. 2022. PMID: 36130732 Free PMC article.
A unique Oct4 interface is crucial for reprogramming to pluripotency.
Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Araúzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR. Esch D, et al. Among authors: jauch r. Nat Cell Biol. 2013 Mar;15(3):295-301. doi: 10.1038/ncb2680. Epub 2013 Feb 3. Nat Cell Biol. 2013. PMID: 23376973
Changing POU dimerization preferences converts Oct6 into a pluripotency inducer.
Jerabek S, Ng CK, Wu G, Arauzo-Bravo MJ, Kim KP, Esch D, Malik V, Chen Y, Velychko S, MacCarthy CM, Yang X, Cojocaru V, Schöler HR, Jauch R. Jerabek S, et al. Among authors: jauch r. EMBO Rep. 2017 Feb;18(2):319-333. doi: 10.15252/embr.201642958. Epub 2016 Dec 22. EMBO Rep. 2017. PMID: 28007765 Free PMC article.
111 results