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Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces.
Hughes JH, Keenan CM, Sutherland H, Edwards HR, Wilson PJM, Ranganath LR, Jarvis JC, Bou-Gharios G, Gallagher JA. Hughes JH, et al. Among authors: jarvis jc. Calcif Tissue Int. 2021 Feb;108(2):207-218. doi: 10.1007/s00223-020-00764-6. Epub 2020 Oct 14. Calcif Tissue Int. 2021. PMID: 33057760 Free PMC article.
Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria.
Ranganath LR, Milan AM, Hughes AT, Khedr M, Davison AS, Shweihdi E, Norman BP, Hughes JH, Bygott H, Luangrath E, Fitzgerald R, Psarelli EE, van Kan C, Laan D, Olsson B, Rudebeck M, Mankowitz L, Sireau N, Arnoux JB, Le Quan Sang KH, Jarvis JC, Genovese F, Braconi D, Santucci A, Zatkova A, Glasova H, Stančík R, Imrich R, Rhodes NP, Gallagher JA. Ranganath LR, et al. Among authors: jarvis jc. J Inherit Metab Dis. 2020 Jul;43(4):737-747. doi: 10.1002/jimd.12181. Epub 2020 Feb 5. J Inherit Metab Dis. 2020. PMID: 31609457
Nitisinone causes acquired tyrosinosis in alkaptonuria.
Khedr M, Cooper MS, Hughes AT, Milan AM, Davison AS, Norman BP, Sutherland H, Jarvis JC, Fitzgerald R, Markinson L, Psarelli EE, Ghane P, Deutz NEP, Gallagher JA, Ranganath LR. Khedr M, et al. Among authors: jarvis jc. J Inherit Metab Dis. 2020 Sep;43(5):1014-1023. doi: 10.1002/jimd.12229. Epub 2020 Mar 5. J Inherit Metab Dis. 2020. PMID: 32083330
Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial.
Ranganath LR, Psarelli EE, Arnoux JB, Braconi D, Briggs M, Bröijersén A, Loftus N, Bygott H, Cox TF, Davison AS, Dillon JP, Fisher M, FitzGerald R, Genovese F, Glasova H, Hall AK, Hughes AT, Hughes JH, Imrich R, Jarvis JC, Khedr M, Laan D, Le Quan Sang KH, Luangrath E, Lukáčová O, Milan AM, Mistry A, Mlynáriková V, Norman BP, Olsson B, Rhodes NP, Rovenský J, Rudebeck M, Santucci A, Shweihdi E, Scott C, Sedláková J, Sireau N, Stančík R, Szamosi J, Taylor S, van Kan C, Vinjamuri S, Vrtíková E, Webb C, West E, Záňová E, Zatkova A, Gallagher JA. Ranganath LR, et al. Among authors: jarvis jc. Lancet Diabetes Endocrinol. 2020 Sep;8(9):762-772. doi: 10.1016/S2213-8587(20)30228-X. Epub 2020 Aug 18. Lancet Diabetes Endocrinol. 2020. PMID: 32822600 Clinical Trial.
Development of an in vitro model to investigate joint ochronosis in alkaptonuria.
Tinti L, Taylor AM, Santucci A, Wlodarski B, Wilson PJ, Jarvis JC, Fraser WD, Davidson JS, Ranganath LR, Gallagher JA. Tinti L, et al. Among authors: jarvis jc. Rheumatology (Oxford). 2011 Feb;50(2):271-7. doi: 10.1093/rheumatology/keq246. Epub 2010 Oct 15. Rheumatology (Oxford). 2011. PMID: 20952450
Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition.
Taylor AM, Preston AJ, Paulk NK, Sutherland H, Keenan CM, Wilson PJ, Wlodarski B, Grompe M, Ranganath LR, Gallagher JA, Jarvis JC. Taylor AM, et al. Among authors: jarvis jc. Osteoarthritis Cartilage. 2012 Aug;20(8):880-6. doi: 10.1016/j.joca.2012.04.013. Epub 2012 Apr 24. Osteoarthritis Cartilage. 2012. PMID: 22542924 Free PMC article.
157 results