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Impaired neuron differentiation in GBA-associated Parkinson's disease is linked to cell cycle defects in organoids.
Rosety I, Zagare A, Saraiva C, Nickels S, Antony P, Almeida C, Glaab E, Halder R, Velychko S, Rauen T, Schöler HR, Bolognin S, Sauter T, Jarazo J, Krüger R, Schwamborn JC. Rosety I, et al. Among authors: jarazo j. NPJ Parkinsons Dis. 2023 Dec 18;9(1):166. doi: 10.1038/s41531-023-00616-8. NPJ Parkinsons Dis. 2023. PMID: 38110400 Free PMC article.
Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1).
Mencke P, Hanss Z, Jarazo J, Massart F, Rybicki A, Petkovski E, Glaab E, Boussaad I, Bonifati V, Christian Schwamborn J, Mandemakers W, Krüger R. Mencke P, et al. Among authors: jarazo j. Stem Cell Res. 2022 Jul;62:102815. doi: 10.1016/j.scr.2022.102815. Epub 2022 May 17. Stem Cell Res. 2022. PMID: 35617842 Free article.
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.
Smajić S, Prada-Medina CA, Landoulsi Z, Ghelfi J, Delcambre S, Dietrich C, Jarazo J, Henck J, Balachandran S, Pachchek S, Morris CM, Antony P, Timmermann B, Sauer S, Pereira SL, Schwamborn JC, May P, Grünewald A, Spielmann M. Smajić S, et al. Among authors: jarazo j. Brain. 2022 Apr 29;145(3):964-978. doi: 10.1093/brain/awab446. Brain. 2022. PMID: 34919646 Free PMC article.
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.
Walter J, Bolognin S, Poovathingal SK, Magni S, Gérard D, Antony PMA, Nickels SL, Salamanca L, Berger E, Smits LM, Grzyb K, Perfeito R, Hoel F, Qing X, Ohnmacht J, Bertacchi M, Jarazo J, Ignac T, Monzel AS, Gonzalez-Cano L, Krüger R, Sauter T, Studer M, de Almeida LP, Tronstad KJ, Sinkkonen L, Skupin A, Schwamborn JC. Walter J, et al. Among authors: jarazo j. Cell Rep. 2021 Oct 19;37(3):109864. doi: 10.1016/j.celrep.2021.109864. Cell Rep. 2021. PMID: 34686322 Free article.
Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment.
Jarazo J, Barmpa K, Modamio J, Saraiva C, Sabaté-Soler S, Rosety I, Griesbeck A, Skwirblies F, Zaffaroni G, Smits LM, Su J, Arias-Fuenzalida J, Walter J, Gomez-Giro G, Monzel AS, Qing X, Vitali A, Cruciani G, Boussaad I, Brunelli F, Jäger C, Rakovic A, Li W, Yuan L, Berger E, Arena G, Bolognin S, Schmidt R, Schröder C, Antony PMA, Klein C, Krüger R, Seibler P, Schwamborn JC. Jarazo J, et al. Mov Disord. 2022 Jan;37(1):80-94. doi: 10.1002/mds.28810. Epub 2021 Oct 12. Mov Disord. 2022. PMID: 34637165 Free PMC article.
PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons.
Brown SJ, Boussaad I, Jarazo J, Fitzgerald JC, Antony P, Keatinge M, Blechman J, Schwamborn JC, Krüger R, Placzek M, Bandmann O. Brown SJ, et al. Among authors: jarazo j. Sci Rep. 2021 Mar 23;11(1):6617. doi: 10.1038/s41598-021-84278-7. Sci Rep. 2021. PMID: 33758225 Free PMC article.
28 results