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Page 1
Selective JAK1 inhibitors for the treatment of inflammatory bowel disease.
Nielsen OH, Boye TL, Gubatan J, Chakravarti D, Jaquith JB, LaCasse EC. Nielsen OH, et al. Among authors: jaquith jb. Pharmacol Ther. 2023 May;245:108402. doi: 10.1016/j.pharmthera.2023.108402. Epub 2023 Mar 31. Pharmacol Ther. 2023. PMID: 37004800 Free article. Review.
Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency.
Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, Roberge M, Nygaard HB. Frew J, et al. Among authors: jaquith jb. Mol Neurodegener. 2020 Mar 16;15(1):21. doi: 10.1186/s13024-020-00369-5. Mol Neurodegener. 2020. PMID: 32178712 Free PMC article.
Novel small molecules potentiate premature termination codon readthrough by aminoglycosides.
Baradaran-Heravi A, Balgi AD, Zimmerman C, Choi K, Shidmoossavee FS, Tan JS, Bergeaud C, Krause A, Flibotte S, Shimizu Y, Anderson HJ, Mouly V, Jan E, Pfeifer T, Jaquith JB, Roberge M. Baradaran-Heravi A, et al. Among authors: jaquith jb. Nucleic Acids Res. 2016 Aug 19;44(14):6583-98. doi: 10.1093/nar/gkw638. Epub 2016 Jul 12. Nucleic Acids Res. 2016. PMID: 27407112 Free PMC article.
Novel spirothiazamenthane inhibitors of the influenza A M2 proton channel.
Arns S, Balgi AD, Shimizu Y, Pfeifer TA, Kumar N, Shidmoossavee FS, Sun S, Tai SS, Agafitei O, Jaquith JB, Bourque E, Niikura M, Roberge M. Arns S, et al. Among authors: jaquith jb. Eur J Med Chem. 2016 Sep 14;120:64-73. doi: 10.1016/j.ejmech.2016.05.008. Epub 2016 May 7. Eur J Med Chem. 2016. PMID: 27187859
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.
Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL. Zahreddine HA, et al. Among authors: jaquith jb. Nature. 2014 Jul 3;511(7507):90-3. doi: 10.1038/nature13283. Epub 2014 May 28. Nature. 2014. PMID: 24870236 Free PMC article.
Cytoprotective effects of IAPs revealed by a small molecule antagonist.
Galbán S, Hwang C, Rumble JM, Oetjen KA, Wright CW, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Duckett CS. Galbán S, et al. Among authors: jaquith jb. Biochem J. 2009 Feb 1;417(3):765-71. doi: 10.1042/BJ20081677. Biochem J. 2009. PMID: 18851715 Free PMC article.