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An oral antisense oligonucleotide for PCSK9 inhibition.
Gennemark P, Walter K, Clemmensen N, Rekić D, Nilsson CAM, Knöchel J, Hölttä M, Wernevik L, Rosengren B, Kakol-Palm D, Wang Y, Yu RZ, Geary RS, Riney SJ, Monia BP, Isaksson R, Jansson-Löfmark R, Rocha CSJ, Lindén D, Hurt-Camejo E, Crooke R, Tillman L, Rydén-Bergsten T, Carlsson B, Andersson U, Elebring M, Tivesten A, Davies N. Gennemark P, et al. Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117. Sci Transl Med. 2021. PMID: 33980578
A modeling approach for compounds affecting body composition.
Gennemark P, Jansson-Löfmark R, Hyberg G, Wigstrand M, Kakol-Palm D, Håkansson P, Hovdal D, Brodin P, Fritsch-Fredin M, Antonsson M, Ploj K, Gabrielsson J. Gennemark P, et al. J Pharmacokinet Pharmacodyn. 2013 Dec;40(6):651-67. doi: 10.1007/s10928-013-9337-x. Epub 2013 Oct 25. J Pharmacokinet Pharmacodyn. 2013. PMID: 24158456
Targeted delivery of antisense oligonucleotides to pancreatic β-cells.
Ämmälä C, Drury WJ 3rd, Knerr L, Ahlstedt I, Stillemark-Billton P, Wennberg-Huldt C, Andersson EM, Valeur E, Jansson-Löfmark R, Janzén D, Sundström L, Meuller J, Claesson J, Andersson P, Johansson C, Lee RG, Prakash TP, Seth PP, Monia BP, Andersson S. Ämmälä C, et al. Sci Adv. 2018 Oct 17;4(10):eaat3386. doi: 10.1126/sciadv.aat3386. eCollection 2018 Oct. Sci Adv. 2018. PMID: 30345352 Free PMC article.
Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs.
Gopaul VS, Pieterman EJ, Princen HMG, Bergenholm L, Lundborg E, Cavallin A, Johansson MJ, Hawthorne G, Björkbom A, Hammarberg M, Li X, Jarke A, Bright J, Svensson L, Jansson-Löfmark R, Abrahamsson B, Agrawal R, Hurt-Camejo E. Gopaul VS, et al. Eur J Pharm Sci. 2021 Jun 1;161:105776. doi: 10.1016/j.ejps.2021.105776. Epub 2021 Mar 2. Eur J Pharm Sci. 2021. PMID: 33667667 Free article.
40 results