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The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M. Loregger A, et al. Among authors: janssen kp. Sci Signal. 2015 Sep 8;8(393):ra90. doi: 10.1126/scisignal.aac6757. Sci Signal. 2015. PMID: 26350900
Mitochondrial function controls intestinal epithelial stemness and proliferation.
Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen KP, Heikenwalder M, Haller D. Berger E, et al. Among authors: janssen kp. Nat Commun. 2016 Oct 27;7:13171. doi: 10.1038/ncomms13171. Nat Commun. 2016. PMID: 27786175 Free PMC article.
Gut microbiota modulate T cell trafficking into human colorectal cancer.
Cremonesi E, Governa V, Garzon JFG, Mele V, Amicarella F, Muraro MG, Trella E, Galati-Fournier V, Oertli D, Däster SR, Droeser RA, Weixler B, Bolli M, Rosso R, Nitsche U, Khanna N, Egli A, Keck S, Slotta-Huspenina J, Terracciano LM, Zajac P, Spagnoli GC, Eppenberger-Castori S, Janssen KP, Borsig L, Iezzi G. Cremonesi E, et al. Among authors: janssen kp. Gut. 2018 Nov;67(11):1984-1994. doi: 10.1136/gutjnl-2016-313498. Epub 2018 Feb 6. Gut. 2018. PMID: 29437871 Free article.
Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.
Coleman OI, Lobner EM, Bierwirth S, Sorbie A, Waldschmitt N, Rath E, Berger E, Lagkouvardos I, Clavel T, McCoy KD, Weber A, Heikenwalder M, Janssen KP, Haller D. Coleman OI, et al. Among authors: janssen kp. Gastroenterology. 2018 Nov;155(5):1539-1552.e12. doi: 10.1053/j.gastro.2018.07.028. Epub 2018 Jul 29. Gastroenterology. 2018. PMID: 30063920 Free article.
Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19.
Schult D, Reitmeier S, Koyumdzhieva P, Lahmer T, Middelhoff M, Erber J, Schneider J, Kager J, Frolova M, Horstmann J, Fricke L, Steiger K, Jesinghaus M, Janssen KP, Protzer U, Neuhaus K, Schmid RM, Haller D, Quante M. Schult D, et al. Among authors: janssen kp. Gut Microbes. 2022 Jan-Dec;14(1):2031840. doi: 10.1080/19490976.2022.2031840. Gut Microbes. 2022. PMID: 35174781 Free PMC article.
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation.
Thiele Orberg E, Meedt E, Hiergeist A, Xue J, Heinrich P, Ru J, Ghimire S, Miltiadous O, Lindner S, Tiefgraber M, Göldel S, Eismann T, Schwarz A, Göttert S, Jarosch S, Steiger K, Schulz C, Gigl M, Fischer JC, Janssen KP, Quante M, Heidegger S, Herhaus P, Verbeek M, Ruland J, van den Brink MRM, Weber D, Edinger M, Wolff D, Busch DH, Kleigrewe K, Herr W, Bassermann F, Gessner A, Deng L, Holler E, Poeck H. Thiele Orberg E, et al. Among authors: janssen kp. Nat Cancer. 2024 Jan;5(1):187-208. doi: 10.1038/s43018-023-00669-x. Epub 2024 Jan 3. Nat Cancer. 2024. PMID: 38172339
192 results