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Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies.
Alexaki A, Hettiarachchi GK, Athey JC, Katneni UK, Simhadri V, Hamasaki-Katagiri N, Nanavaty P, Lin B, Takeda K, Freedberg D, Monroe D, McGill JR, Peters R, Kames JM, Holcomb DD, Hunt RC, Sauna ZE, Gelinas A, Janjic N, DiCuccio M, Bar H, Komar AA, Kimchi-Sarfaty C. Alexaki A, et al. Among authors: janjic n. Sci Rep. 2019 Oct 29;9(1):15449. doi: 10.1038/s41598-019-51984-2. Sci Rep. 2019. PMID: 31664102 Free PMC article.
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand.
Gelinas AD, Davies DR, Edwards TE, Rohloff JC, Carter JD, Zhang C, Gupta S, Ishikawa Y, Hirota M, Nakaishi Y, Jarvis TC, Janjic N. Gelinas AD, et al. Among authors: janjic n. J Biol Chem. 2014 Mar 21;289(12):8720-34. doi: 10.1074/jbc.M113.532697. Epub 2014 Jan 12. J Biol Chem. 2014. PMID: 24415767 Free PMC article.
Embracing proteins: structural themes in aptamer-protein complexes.
Gelinas AD, Davies DR, Janjic N. Gelinas AD, et al. Among authors: janjic n. Curr Opin Struct Biol. 2016 Feb;36:122-32. doi: 10.1016/j.sbi.2016.01.009. Epub 2016 Feb 24. Curr Opin Struct Biol. 2016. PMID: 26919170 Free article. Review.
Rapid histochemistry using slow off-rate modified aptamers with anionic competition.
Gupta S, Thirstrup D, Jarvis TC, Schneider DJ, Wilcox SK, Carter J, Zhang C, Gelinas A, Weiss A, Janjic N, Baird GS. Gupta S, et al. Among authors: janjic n. Appl Immunohistochem Mol Morphol. 2011 May;19(3):273-8. doi: 10.1097/PAI.0b013e3182008c29. Appl Immunohistochem Mol Morphol. 2011. PMID: 21217521
Modified nucleotides may have enhanced early RNA catalysis.
Wolk SK, Mayfield WS, Gelinas AD, Astling D, Guillot J, Brody EN, Janjic N, Gold L. Wolk SK, et al. Among authors: janjic n. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8236-8242. doi: 10.1073/pnas.1809041117. Epub 2020 Mar 30. Proc Natl Acad Sci U S A. 2020. PMID: 32229566 Free PMC article.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Davies DR, Gelinas AD, Zhang C, Rohloff JC, Carter JD, O'Connell D, Waugh SM, Wolk SK, Mayfield WS, Burgin AB, Edwards TE, Stewart LJ, Gold L, Janjic N, Jarvis TC. Davies DR, et al. Among authors: janjic n. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19971-6. doi: 10.1073/pnas.1213933109. Epub 2012 Nov 8. Proc Natl Acad Sci U S A. 2012. PMID: 23139410 Free PMC article.
106 results