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Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition.
Nowicki-Osuch K, Zhuang L, Jammula S, Bleaney CW, Mahbubani KT, Devonshire G, Katz-Summercorn A, Eling N, Wilbrey-Clark A, Madissoon E, Gamble J, Di Pietro M, O'Donovan M, Meyer KB, Saeb-Parsy K, Sharrocks AD, Teichmann SA, Marioni JC, Fitzgerald RC. Nowicki-Osuch K, et al. Among authors: jammula s. Science. 2021 Aug 13;373(6556):760-767. doi: 10.1126/science.abd1449. Science. 2021. PMID: 34385390
Multi-omic cross-sectional cohort study of pre-malignant Barrett's esophagus reveals early structural variation and retrotransposon activity.
Katz-Summercorn AC, Jammula S, Frangou A, Peneva I, O'Donovan M, Tripathi M, Malhotra S, di Pietro M, Abbas S, Devonshire G, Januszewicz W, Blasko A, Nowicki-Osuch K, MacRae S, Northrop A, Redmond AM, Wedge DC, Fitzgerald RC. Katz-Summercorn AC, et al. Among authors: jammula s. Nat Commun. 2022 Mar 17;13(1):1407. doi: 10.1038/s41467-022-28237-4. Nat Commun. 2022. PMID: 35301290 Free PMC article.
DNA Methylation Biomarkers for the Diagnosis of Barrett's Oesophagus.
Kosmidou C, Jammula S, Fitzgerald RC. Kosmidou C, et al. Among authors: jammula s. Am J Gastroenterol. 2018 Nov;113(11):1722. doi: 10.1038/s41395-018-0226-1. Epub 2018 Oct 17. Am J Gastroenterol. 2018. PMID: 30333547 Free PMC article. No abstract available.
Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data.
Jammula S, Katz-Summercorn AC, Li X, Linossi C, Smyth E, Killcoyne S, Biasci D, Subash VV, Abbas S, Blasko A, Devonshire G, Grantham A, Wronowski F, O'Donovan M, Grehan N, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium; Fitzgerald RC. Jammula S, et al. Gastroenterology. 2020 May;158(6):1682-1697.e1. doi: 10.1053/j.gastro.2020.01.044. Epub 2020 Feb 4. Gastroenterology. 2020. PMID: 32032585 Free PMC article.
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic.
Frankell AM, Jammula S, Li X, Contino G, Killcoyne S, Abbas S, Perner J, Bower L, Devonshire G, Ococks E, Grehan N, Mok J, O'Donovan M, MacRae S, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium; Fitzgerald RC. Frankell AM, et al. Among authors: jammula s. Nat Genet. 2019 Mar;51(3):506-516. doi: 10.1038/s41588-018-0331-5. Epub 2019 Feb 4. Nat Genet. 2019. PMID: 30718927 Free PMC article.
Selection and Application of Tissue microRNAs for Nonendoscopic Diagnosis of Barrett's Esophagus.
Li X, Kleeman S, Coburn SB, Fumagalli C, Perner J, Jammula S, Pfeiffer RM, Orzolek L, Hao H, Taylor PR, Miremadi A, Galeano-Dalmau N, Lao-Sirieix P, Tennyson M, MacRae S, Cook MB, Fitzgerald RC. Li X, et al. Among authors: jammula s. Gastroenterology. 2018 Sep;155(3):771-783.e3. doi: 10.1053/j.gastro.2018.05.050. Epub 2018 Jun 12. Gastroenterology. 2018. PMID: 29906417 Free PMC article.
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas.
Ng AWT, Contino G, Killcoyne S, Devonshire G, Hsu R, Abbas S, Su J, Redmond AM, Weaver JMJ, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium; Edwards PAW, Fitzgerald RC. Ng AWT, et al. Commun Biol. 2022 Apr 8;5(1):335. doi: 10.1038/s42003-022-03238-7. Commun Biol. 2022. PMID: 35396535 Free PMC article.
Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus.
Knight WRC, McEwen R, Byrne BE, Habib W, Bott R, Zylstra J, Mahadeva U, Gossage JA; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium. Knight WRC, et al. Eur J Surg Oncol. 2020 Dec;46(12):2257-2261. doi: 10.1016/j.ejso.2020.07.003. Epub 2020 Jul 28. Eur J Surg Oncol. 2020. PMID: 32814680
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma.
Turkington RC, Knight LA, Blayney JK, Secrier M, Douglas R, Parkes EE, Sutton EK, Stevenson L, McManus D, Halliday S, McCavigan AM, Logan GE, Walker SM, Steele CJ, Perner J, Bornschein J, MacRae S, Miremadi A, McCarron E, McQuaid S, Arthur K, James JA, Eatock MM, O'Neill R, Noble F, Underwood TJ, Harkin DP, Salto-Tellez M, Fitzgerald RC, Kennedy RD; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group. Turkington RC, et al. Gut. 2019 Nov;68(11):1918-1927. doi: 10.1136/gutjnl-2018-317624. Epub 2019 Mar 9. Gut. 2019. PMID: 30852560 Free PMC article.
83 results