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Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists.
Mahindra A, Jenkins L, Marsango S, Huggett M, Huggett M, Robinson L, Gillespie J, Rajamanickam M, Morrison A, McElroy S, Tikhonova IG, Milligan G, Jamieson AG. Mahindra A, et al. Among authors: jamieson ag. J Med Chem. 2022 Aug 25;65(16):11270-11290. doi: 10.1021/acs.jmedchem.2c00804. Epub 2022 Aug 10. J Med Chem. 2022. PMID: 35948061 Free PMC article.
Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalization.
Morgan DC, Morris C, Mahindra A, Blair CM, Tejeda G, Herbert I, Turnbull ML, Lieber G, Willett BJ, Logan N, Smith B, Tobin AB, Bhella D, Baillie G, Jamieson AG. Morgan DC, et al. Among authors: jamieson ag. Pept Sci (Hoboken). 2021 Jul;113(4):e24217. doi: 10.1002/pep2.24217. Epub 2021 Jan 8. Pept Sci (Hoboken). 2021. PMID: 33615115 Free PMC article.
Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction.
Mahindra A, Tejeda G, Rossi M, Janha O, Herbert I, Morris C, Morgan DC, Beattie W, Montezano AC, Hudson B, Tobin AB, Bhella D, Touyz RM, Jamieson AG, Baillie GS, Blair CM. Mahindra A, et al. Among authors: jamieson ag. PLoS One. 2021 Nov 18;16(11):e0260283. doi: 10.1371/journal.pone.0260283. eCollection 2021. PLoS One. 2021. PMID: 34793553 Free PMC article.
Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
Yelland T, Garcia E, Parry C, Kowalczyk D, Wojnowska M, Gohlke A, Zalar M, Cameron K, Goodwin G, Yu Q, Zhu PC, ElMaghloob Y, Pugliese A, Archibald L, Jamieson A, Chen YX, McArthur D, Bower J, Ismail S. Yelland T, et al. J Med Chem. 2022 Feb 10;65(3):1898-1914. doi: 10.1021/acs.jmedchem.1c01265. Epub 2022 Feb 1. J Med Chem. 2022. PMID: 35104933 Free PMC article.
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.
Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, Solyakov L, Dudek K, Jones C, Zapatero C, Doerig C, Nwakanma DC, Vázquez MJ, Colmenarejo G, Lafuente-Monasterio MJ, Leon ML, Godoi PHC, Elkins JM, Waters AP, Jamieson AG, Álvaro EF, Ranford-Cartwright LC, Marti M, Winzeler EA, Gamo FJ, Tobin AB. Alam MM, et al. Among authors: jamieson ag. Science. 2019 Aug 30;365(6456):eaau1682. doi: 10.1126/science.aau1682. Science. 2019. PMID: 31467193 Free article.
49 results