James MO - Search Results

1

Dichloroacetate-induced peripheral neuropathy.

Stacpoole PW, Martyniuk CJ, James MO, Calcutt NA. Stacpoole PW, et al. Among authors: james mo. Int Rev Neurobiol. 2019;145:211-238. doi: 10.1016/bs.irn.2019.05.003. Epub 2019 Jun 11. Int Rev Neurobiol. 2019. PMID: 31208525 Review.

2

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

Shroads AL, Guo X, Dixit V, Liu HP, James MO, Stacpoole PW. Shroads AL, et al. Among authors: james mo. J Pharmacol Exp Ther. 2008 Mar;324(3):1163-71. doi: 10.1124/jpet.107.134593. Epub 2007 Dec 20. J Pharmacol Exp Ther. 2008. PMID: 18096758 Free PMC article.

3

Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW. Li W, et al. Among authors: james mo. J Pharmacol Exp Ther. 2011 Jan;336(1):87-94. doi: 10.1124/jpet.110.173195. Epub 2010 Sep 30. J Pharmacol Exp Ther. 2011. PMID: 20884751 Free PMC article.

4

Pharmacokinetics of oral dichloroacetate in dogs.

Maisenbacher HW 3rd, Shroads AL 3rd, Zhong G, Daigle AD, Abdelmalak MM, Samper IS, Mincey BD, James MO, Stacpoole PW. Maisenbacher HW 3rd, et al. Among authors: james mo. J Biochem Mol Toxicol. 2013 Dec;27(12):522-5. doi: 10.1002/jbt.21518. Epub 2013 Sep 13. J Biochem Mol Toxicol. 2013. PMID: 24038869

5

Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.

Zhong G, Li W, Gu Y, Langaee T, Stacpoole PW, James MO. Zhong G, et al. Among authors: james mo. Chem Biol Interact. 2014 May 25;215:33-9. doi: 10.1016/j.cbi.2014.02.015. Epub 2014 Mar 13. Chem Biol Interact. 2014. PMID: 24632415 Free PMC article.

6

Pharmacogenetic considerations with dichloroacetate dosing.

James MO, Stacpoole PW. James MO, et al. Pharmacogenomics. 2016 May;17(7):743-53. doi: 10.2217/pgs-2015-0012. Epub 2016 May 4. Pharmacogenomics. 2016. PMID: 27143230 Free PMC article. Review.

7

Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. James MO, et al. Pharmacol Ther. 2017 Feb;170:166-180. doi: 10.1016/j.pharmthera.2016.10.018. Epub 2016 Oct 19. Pharmacol Ther. 2017. PMID: 27771434 Free PMC article. Review.

8

Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.

Mangal N, James MO, Stacpoole PW, Schmidt S. Mangal N, et al. Among authors: james mo. J Clin Pharmacol. 2018 Feb;58(2):212-220. doi: 10.1002/jcph.1009. Epub 2017 Sep 15. J Clin Pharmacol. 2018. PMID: 28914978 Free PMC article. Clinical Trial.

9

Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.

Squirewell EJ, Mareus R, Horne LP, Stacpoole PW, James MO. Squirewell EJ, et al. Among authors: james mo. Drug Metab Dispos. 2020 Nov;48(11):1224-1230. doi: 10.1124/dmd.120.000143. Epub 2020 Sep 1. Drug Metab Dispos. 2020. PMID: 32873592 Free PMC article.

10

Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.

Squirewell EJ, Smeltz MG, Rowland-Faux L, Horne LP, Stacpoole PW, James MO. Squirewell EJ, et al. Among authors: james mo. Drug Metab Dispos. 2020 Nov;48(11):1217-1223. doi: 10.1124/dmd.120.000142. Epub 2020 Sep 1. Drug Metab Dispos. 2020. PMID: 32873593 Free PMC article.

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