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A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.
Maruggi G, Mallett CP, Westerbeck JW, Chen T, Lofano G, Friedrich K, Qu L, Sun JT, McAuliffe J, Kanitkar A, Arrildt KT, Wang KF, McBee I, McCoy D, Terry R, Rowles A, Abrahim MA, Ringenberg MA, Gains MJ, Spickler C, Xie X, Zou J, Shi PY, Dutt T, Henao-Tamayo M, Ragan I, Bowen RA, Johnson R, Nuti S, Luisi K, Ulmer JB, Steff AM, Jalah R, Bertholet S, Stokes AH, Yu D. Maruggi G, et al. Among authors: jalah r. Mol Ther. 2022 May 4;30(5):1897-1912. doi: 10.1016/j.ymthe.2022.01.001. Epub 2022 Jan 3. Mol Ther. 2022. PMID: 34990810 Free PMC article. Clinical Trial.
Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.
Kulkarni V, Rosati M, Valentin A, Jalah R, Alicea C, Yu L, Guan Y, Shen X, Tomaras GD, LaBranche C, Montefiori DC, Irene C, Prattipati R, Pinter A, Sullivan SM, Pavlakis GN, Felber BK. Kulkarni V, et al. Among authors: jalah r. Hum Vaccin Immunother. 2013 Oct;9(10):2069-80. doi: 10.4161/hv.25442. Epub 2013 Jul 2. Hum Vaccin Immunother. 2013. PMID: 23820294 Free PMC article.
Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation.
Rosati M, Valentin A, Jalah R, Patel V, von Gegerfelt A, Bergamaschi C, Alicea C, Weiss D, Treece J, Pal R, Markham PD, Marques ET, August JT, Khan A, Draghia-Akli R, Felber BK, Pavlakis GN. Rosati M, et al. Among authors: jalah r. Vaccine. 2008 Sep 19;26(40):5223-9. doi: 10.1016/j.vaccine.2008.03.090. Epub 2008 Apr 21. Vaccine. 2008. PMID: 18468743 Free PMC article.
Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization.
Patel V, Valentin A, Kulkarni V, Rosati M, Bergamaschi C, Jalah R, Alicea C, Minang JT, Trivett MT, Ohlen C, Zhao J, Robert-Guroff M, Khan AS, Draghia-Akli R, Felber BK, Pavlakis GN. Patel V, et al. Among authors: jalah r. Vaccine. 2010 Jul 5;28(30):4827-36. doi: 10.1016/j.vaccine.2010.04.064. Epub 2010 May 6. Vaccine. 2010. PMID: 20451642 Free PMC article.
Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.
Kulkarni V, Jalah R, Ganneru B, Bergamaschi C, Alicea C, von Gegerfelt A, Patel V, Zhang GM, Chowdhury B, Broderick KE, Sardesai NY, Valentin A, Rosati M, Felber BK, Pavlakis GN. Kulkarni V, et al. Among authors: jalah r. Vaccine. 2011 Sep 9;29(39):6742-54. doi: 10.1016/j.vaccine.2010.12.056. Epub 2010 Dec 30. Vaccine. 2011. PMID: 21195080 Free PMC article.
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
Jalah R, Patel V, Kulkarni V, Rosati M, Alicea C, Ganneru B, von Gegerfelt A, Huang W, Guan Y, Broderick KE, Sardesai NY, LaBranche C, Montefiori DC, Pavlakis GN, Felber BK. Jalah R, et al. Hum Vaccin Immunother. 2012 Nov 1;8(11):1620-9. doi: 10.4161/hv.21407. Epub 2012 Aug 16. Hum Vaccin Immunother. 2012. PMID: 22894956 Free PMC article.
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
Jalah R, Rosati M, Ganneru B, Pilkington GR, Valentin A, Kulkarni V, Bergamaschi C, Chowdhury B, Zhang GM, Beach RK, Alicea C, Broderick KE, Sardesai NY, Pavlakis GN, Felber BK. Jalah R, et al. J Biol Chem. 2013 Mar 1;288(9):6763-76. doi: 10.1074/jbc.M112.436675. Epub 2013 Jan 7. J Biol Chem. 2013. PMID: 23297419 Free PMC article.
37 results