Jadhav V - Search Results

1

Post-Synthetic Modification of Oligonucleotides via Orthogonal Amidation and Copper Catalyzed Cycloaddition Reactions.

Zewge D, Butora G, Sherer EC, Tellers DM, Sidler DR, Gouker J, Copeland G, Jadhav V, Li Z, Armstrong J, Davies IW. Zewge D, et al. Among authors: jadhav v. Bioconjug Chem. 2018 Jun 20;29(6):1859-1865. doi: 10.1021/acs.bioconjchem.8b00298. Epub 2018 Jun 12. Bioconjug Chem. 2018. PMID: 29893553

2

High-throughput chemical modification of oligonucleotides for systematic structure-activity relationship evaluation.

Zewge D, Gosselin F, Kenski DM, Li J, Jadhav V, Yuan Y, Nerurkar SS, Tellers DM, Flanagan WM, Davies IW. Zewge D, et al. Among authors: jadhav v. Bioconjug Chem. 2014 Dec 17;25(12):2222-32. doi: 10.1021/bc500453q. Epub 2014 Nov 21. Bioconjug Chem. 2014. PMID: 25398098

3

Molecular umbrella conjugate for the ocular delivery of siRNA.

Janout V, Cline LL, Feuston BP, Klein L, O'Brien A, Tucker T, Yuan Y, O'Neill-Davis LA, Peiffer RL, Nerurkar SS, Jadhav V, Tellers DM, Regen SL. Janout V, et al. Among authors: jadhav v. Bioconjug Chem. 2014 Feb 19;25(2):197-201. doi: 10.1021/bc400506m. Epub 2014 Jan 23. Bioconjug Chem. 2014. PMID: 24433067 Free PMC article.

4

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape.

Bartz R, Fan H, Zhang J, Innocent N, Cherrin C, Beck SC, Pei Y, Momose A, Jadhav V, Tellers DM, Meng F, Crocker LS, Sepp-Lorenzino L, Barnett SF. Bartz R, et al. Among authors: jadhav v. Biochem J. 2011 Apr 15;435(2):475-87. doi: 10.1042/BJ20101021. Biochem J. 2011. PMID: 21265735

5

Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation.

Zhang Y, Bartz R, Grigoryan G, Bryant M, Aaronson J, Beck S, Innocent N, Klein L, Procopio W, Tucker T, Jadhav V, Tellers DM, DeGrado WF. Zhang Y, et al. Among authors: jadhav v. ACS Chem Biol. 2015 Apr 17;10(4):1082-93. doi: 10.1021/cb500759p. Epub 2015 Jan 28. ACS Chem Biol. 2015. PMID: 25630033 Free PMC article.

6

Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG. Parmar RG, et al. Among authors: jadhav v. J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27. J Med Chem. 2018. PMID: 29376650

7

Examination of real-time polymerase chain reaction methods for the detection and quantification of modified siRNA.

Stratford S, Stec S, Jadhav V, Seitzer J, Abrams M, Beverly M. Stratford S, et al. Among authors: jadhav v. Anal Biochem. 2008 Aug 1;379(1):96-104. doi: 10.1016/j.ab.2008.05.001. Epub 2008 May 4. Anal Biochem. 2008. PMID: 18501185

8

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V. Parmar R, et al. Among authors: jadhav v. Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28. Chembiochem. 2016. PMID: 27121751

9

5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. Zlatev I, et al. Among authors: jadhav v. ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13. ACS Chem Biol. 2016. PMID: 26675211

10

Centyrin ligands for extrahepatic delivery of siRNA.

Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Mendrola Zarazowski J, Jadhav V, Maier MA, Sepp-Lorenzino L, O'Neil K, Dudkin V. Klein D, et al. Among authors: jadhav v. Mol Ther. 2021 Jun 2;29(6):2053-2066. doi: 10.1016/j.ymthe.2021.02.015. Epub 2021 Feb 15. Mol Ther. 2021. PMID: 33601052 Free PMC article.

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