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Hypnotics with novel modes of action.
Hoyer D, Allen A, Jacobson LH. Hoyer D, et al. Among authors: jacobson lh. Br J Clin Pharmacol. 2020 Feb;86(2):244-249. doi: 10.1111/bcp.14180. Epub 2020 Jan 17. Br J Clin Pharmacol. 2020. PMID: 31756268 Free PMC article. Review.
mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.
Fendt M, Schmid S, Thakker DR, Jacobson LH, Yamamoto R, Mitsukawa K, Maier R, Natt F, Hüsken D, Kelly PH, McAllister KH, Hoyer D, van der Putten H, Cryan JF, Flor PJ. Fendt M, et al. Among authors: jacobson lh. Mol Psychiatry. 2008 Oct;13(10):970-9. doi: 10.1038/sj.mp.4002073. Epub 2007 Aug 21. Mol Psychiatry. 2008. PMID: 17712315
Distinct effects of IPSU and suvorexant on mouse sleep architecture.
Hoyer D, Dürst T, Fendt M, Jacobson LH, Betschart C, Hintermann S, Behnke D, Cotesta S, Laue G, Ofner S, Legangneux E, Gee CE. Hoyer D, et al. Among authors: jacobson lh. Front Neurosci. 2013 Dec 10;7:235. doi: 10.3389/fnins.2013.00235. eCollection 2013. Front Neurosci. 2013. PMID: 24368893 Free PMC article.
Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.
Callander GE, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Laue G, Ofner S, Briard E, Gee CE, Jacobson LH, Hoyer D. Callander GE, et al. Among authors: jacobson lh. Front Neurosci. 2013 Dec 3;7:230. doi: 10.3389/fnins.2013.00230. eCollection 2013. Front Neurosci. 2013. PMID: 24376396 Free PMC article.
Suvorexant for the treatment of insomnia.
Jacobson LH, Callander GE, Hoyer D. Jacobson LH, et al. Expert Rev Clin Pharmacol. 2014 Nov;7(6):711-30. doi: 10.1586/17512433.2014.966813. Expert Rev Clin Pharmacol. 2014. PMID: 25318834 Review.
Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).
Behnke D, Cotesta S, Hintermann S, Fendt M, Gee CE, Jacobson LH, Laue G, Meyer A, Wagner T, Badiger S, Chaudhari V, Chebrolu M, Pandit C, Hoyer D, Betschart C. Behnke D, et al. Among authors: jacobson lh. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5555-60. doi: 10.1016/j.bmcl.2015.10.055. Epub 2015 Oct 19. Bioorg Med Chem Lett. 2015. PMID: 26522950
Orexin OX2 Receptor Antagonists as Sleep Aids.
Jacobson LH, Chen S, Mir S, Hoyer D. Jacobson LH, et al. Curr Top Behav Neurosci. 2017;33:105-136. doi: 10.1007/7854_2016_47. Curr Top Behav Neurosci. 2017. PMID: 27909987 Review.
69 results