Jacobson IC - Search Results

1

Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors.

Varnes JG, Wacker DA, Jacobson IC, Quan ML, Ellis CD, Rossi KA, He MY, Luettgen JM, Knabb RM, Bai S, He K, Lam PY, Wexler RR. Varnes JG, et al. Among authors: jacobson ic. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6481-8. doi: 10.1016/j.bmcl.2007.09.091. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17933529

2

Sulfonamidolactam inhibitors of coagulation factor Xa.

Smallheer JM, Wang S, Laws ML, Nakajima S, Hu Z, Han W, Jacobson I, Luettgen JM, Rossi KA, Rendina AR, Knabb RM, Wexler RR, Lam PY, Quan ML. Smallheer JM, et al. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2428-33. doi: 10.1016/j.bmcl.2008.02.054. Epub 2008 Feb 26. Bioorg Med Chem Lett. 2008. PMID: 18329876

3

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.

Fevig JM, Pinto DJ, Han Q, Quan ML, Pruitt JR, Jacobson IC, Galemmo RA Jr, Wang S, Orwat MJ, Bostrom LL, Knabb RM, Wong PC, Lam PYS, Wexler RR. Fevig JM, et al. Among authors: jacobson ic. Bioorg Med Chem Lett. 2001 Mar 12;11(5):641-5. doi: 10.1016/s0960-894x(01)00029-4. Bioorg Med Chem Lett. 2001. PMID: 11266160

4

Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: jacobson ic. J Med Chem. 2001 Aug 2;44(16):2636-60. doi: 10.1021/jm010127e. J Med Chem. 2001. PMID: 11472217

5

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.

Jacobson IC, Reddy PG, Wasserman ZR, Hardman KD, Covington MB, Arner EC, Copeland RA, Decicco CP, Magolda RL. Jacobson IC, et al. Bioorg Med Chem Lett. 1998 Apr 7;8(7):837-42. doi: 10.1016/s0960-894x(98)00125-5. Bioorg Med Chem Lett. 1998. PMID: 9871551

6

Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium.

Pitts WJ, Jetter JW, Pinto DJ, Orwat MJ, Batt DG, Sherk SR, Petraitis JJ, Jacobson IC, Copeland RA, Dowling RL, Jaffee BD, Gardner TL, Jones EA, Magolda RL. Pitts WJ, et al. Among authors: jacobson ic. Bioorg Med Chem Lett. 1998 Feb 3;8(3):307-12. doi: 10.1016/s0960-894x(98)00010-9. Bioorg Med Chem Lett. 1998. PMID: 9871675

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