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MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Lee-Sherick AB, Jacobsen KM, Henry CJ, Huey MG, Parker RE, Page LS, Hill AA, Wang X, Frye SV, Earp HS, Jordan CT, DeRyckere D, Graham DK. Lee-Sherick AB, et al. Among authors: jacobsen km. JCI Insight. 2018 Nov 2;3(21):e97941. doi: 10.1172/jci.insight.97941. JCI Insight. 2018. PMID: 30385715 Free PMC article.
UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models.
DeRyckere D, Lee-Sherick AB, Huey MG, Hill AA, Tyner JW, Jacobsen KM, Page LS, Kirkpatrick GG, Eryildiz F, Montgomery SA, Zhang W, Wang X, Frye SV, Earp HS, Graham DK. DeRyckere D, et al. Among authors: jacobsen km. Clin Cancer Res. 2017 Mar 15;23(6):1481-1492. doi: 10.1158/1078-0432.CCR-16-1330. Epub 2016 Sep 20. Clin Cancer Res. 2017. PMID: 27649555 Free PMC article.
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Lee-Sherick AB, Jacobsen KM, Henry CJ, Huey MG, Parker RE, Page LS, Hill AA, Wang X, Frye SV, Earp HS, Jordan CT, DeRyckere D, Graham DK. Lee-Sherick AB, et al. Among authors: jacobsen km. JCI Insight. 2020 Dec 3;5(23):e145847. doi: 10.1172/jci.insight.145847. JCI Insight. 2020. PMID: 33268596 Free PMC article. No abstract available.
MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.
Cook RS, Jacobsen KM, Wofford AM, DeRyckere D, Stanford J, Prieto AL, Redente E, Sandahl M, Hunter DM, Strunk KE, Graham DK, Earp HS 3rd. Cook RS, et al. Among authors: jacobsen km. J Clin Invest. 2013 Aug;123(8):3231-42. doi: 10.1172/JCI67655. Epub 2013 Jul 8. J Clin Invest. 2013. PMID: 23867499 Free PMC article.
A cell-based high-throughput screen to identify synergistic TRAIL sensitizers.
Booth NL, Sayers TJ, Brooks AD, Thomas CL, Jacobsen K, Goncharova EI, McMahon JB, Henrich CJ. Booth NL, et al. Cancer Immunol Immunother. 2009 Aug;58(8):1229-44. doi: 10.1007/s00262-008-0637-8. Epub 2008 Dec 17. Cancer Immunol Immunother. 2009. PMID: 19089423 Free PMC article.
23 results