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COVID-19 therapy: What weapons do we bring into battle?
de Almeida SMV, Santos Soares JC, Dos Santos KL, Alves JEF, Ribeiro AG, Jacob ÍTT, da Silva Ferreira CJ, Dos Santos JC, de Oliveira JF, de Carvalho Junior LB, de Lima MDCA. de Almeida SMV, et al. Among authors: jacob itt. Bioorg Med Chem. 2020 Dec 1;28(23):115757. doi: 10.1016/j.bmc.2020.115757. Epub 2020 Sep 10. Bioorg Med Chem. 2020. PMID: 32992245 Free PMC article.
Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.
Moraes ADTO, Miranda MDS, Jacob ÍTT, Amorim CADC, Moura RO, Silva SÂSD, Soares MBP, Almeida SMV, Souza TRCL, Oliveira JF, Silva TGD, Melo CML, Moreira DRM, Lima MDCA. Moraes ADTO, et al. Among authors: jacob itt. Bioorg Med Chem. 2018 Nov 1;26(20):5388-5396. doi: 10.1016/j.bmc.2018.07.024. Epub 2018 Jul 17. Bioorg Med Chem. 2018. PMID: 30293795
Pectin-like polysaccharide extracted from leaves Crataeva tapia promotes antioxidant, immunomodulatory and emulsifiers applied in therapeutic formulations.
da Paz Leôncio Alves S, Jacob ITT, Arruda MDM, da Silva AR, de Sousa GF, de Souza GA, de Lima MDCA, de Souza IA, de Melo CML, da Cruz Filho IJ, do Nascimento Santos DKD. da Paz Leôncio Alves S, et al. Among authors: jacob itt. 3 Biotech. 2023 Apr;13(4):114. doi: 10.1007/s13205-023-03509-y. Epub 2023 Mar 9. 3 Biotech. 2023. PMID: 36909979 Free PMC article.
Thiazolidine derivatives: In vitro toxicity assessment against promastigote and amastigote forms of Leishmania infantum and ultrastructural study.
Gouveia ALA, Santos FAB, Alves LC, Cruz-Filho IJ, Silva PR, Jacob ITT, Soares JCS, Santos DKDN, Souza TRCL, Oliveira JF, Lima MDCA. Gouveia ALA, et al. Among authors: jacob itt. Exp Parasitol. 2022 May-Jun;236-237:108253. doi: 10.1016/j.exppara.2022.108253. Epub 2022 Apr 4. Exp Parasitol. 2022. PMID: 35381223
Synthesis and Anticancer Evaluation of Thiazacridine Derivatives Reveals New Selective Molecules to Hematopoietic Neoplastic Cells.
de Melo Rego MJB, de Sena WLB, de Moura RO, Jacob ITT, Lins E Lins TU, Pereira MC, do Carmo A Lima M, Galdino-Pitta MR, da R Pitta I, da Rocha Pitta MG. de Melo Rego MJB, et al. Among authors: jacob itt. Comb Chem High Throughput Screen. 2017;20(8):713-718. doi: 10.2174/1386207320666170724114802. Comb Chem High Throughput Screen. 2017. PMID: 28738767