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Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jørgensen C. Hutton C, et al. Among authors: jorgensen c. Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22. Cancer Cell. 2021. PMID: 34297917 Free PMC article.
Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.
Girotti MR, Pedersen M, Sanchez-Laorden B, Viros A, Turajlic S, Niculescu-Duvaz D, Zambon A, Sinclair J, Hayes A, Gore M, Lorigan P, Springer C, Larkin J, Jorgensen C, Marais R. Girotti MR, et al. Among authors: jorgensen c. Cancer Discov. 2013 Feb;3(2):158-67. doi: 10.1158/2159-8290.CD-12-0386. Epub 2012 Dec 14. Cancer Discov. 2013. PMID: 23242808 Free PMC article.
Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation.
Tape CJ, Ling S, Dimitriadi M, McMahon KM, Worboys JD, Leong HS, Norrie IC, Miller CJ, Poulogiannis G, Lauffenburger DA, Jørgensen C. Tape CJ, et al. Among authors: jorgensen c. Cell. 2016 May 5;165(4):910-20. doi: 10.1016/j.cell.2016.03.029. Epub 2016 Apr 14. Cell. 2016. PMID: 27087446 Free PMC article.
Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy.
Pelly VS, Moeini A, Roelofsen LM, Bonavita E, Bell CR, Hutton C, Blanco-Gomez A, Banyard A, Bromley CP, Flanagan E, Chiang SC, Jørgensen C, Schumacher TN, Thommen DS, Zelenay S. Pelly VS, et al. Among authors: jorgensen c. Cancer Discov. 2021 Oct;11(10):2602-2619. doi: 10.1158/2159-8290.CD-20-1815. Epub 2021 May 24. Cancer Discov. 2021. PMID: 34031121 Free PMC article.
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids.
Below CR, Kelly J, Brown A, Humphries JD, Hutton C, Xu J, Lee BY, Cintas C, Zhang X, Hernandez-Gordillo V, Stockdale L, Goldsworthy MA, Geraghty J, Foster L, O'Reilly DA, Schedding B, Askari J, Burns J, Hodson N, Smith DL, Lally C, Ashton G, Knight D, Mironov A, Banyard A, Eble JA, Morton JP, Humphries MJ, Griffith LG, Jørgensen C. Below CR, et al. Among authors: jorgensen c. Nat Mater. 2022 Jan;21(1):110-119. doi: 10.1038/s41563-021-01085-1. Epub 2021 Sep 13. Nat Mater. 2022. PMID: 34518665 Free PMC article.
FAK scaffolds immune escape in pancreatic cancer.
Blanco-Gomez A, Jorgensen C. Blanco-Gomez A, et al. Among authors: jorgensen c. Gut. 2023 Dec 7;73(1):6-8. doi: 10.1136/gutjnl-2023-330049. Gut. 2023. PMID: 37280041 No abstract available.
1,298 results