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Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.
Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, De Masi F, Munkbøl CH, Styrishave B, Antignac JP, Le Bizec B, Platel C, Hay-Schmidt A, Jensen TK, Lesné L, Mazaud-Guittot S, Kristiansen K, Brunak S, Kjaer M, Juul A, Jégou B. Kristensen DM, et al. Among authors: jegou b. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311296 Free PMC article. Clinical Trial.
Ibuprofen results in alterations of human fetal testis development.
Ben Maamar M, Lesné L, Hennig K, Desdoits-Lethimonier C, Kilcoyne KR, Coiffec I, Rolland AD, Chevrier C, Kristensen DM, Lavoué V, Antignac JP, Le Bizec B, Dejucq-Rainsford N, Mitchell RT, Mazaud-Guittot S, Jégou B. Ben Maamar M, et al. Among authors: jegou b. Sci Rep. 2017 Mar 10;7:44184. doi: 10.1038/srep44184. Sci Rep. 2017. PMID: 28281692 Free PMC article.
Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.
Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S, Skakkebaek NE, Nellemann C, Main KM, Jégou B, Leffers H. Kristensen DM, et al. Among authors: jegou b. Hum Reprod. 2011 Jan;26(1):235-44. doi: 10.1093/humrep/deq323. Epub 2010 Nov 8. Hum Reprod. 2011. PMID: 21059752
Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.
Mazaud-Guittot S, Nicolas Nicolaz C, Desdoits-Lethimonier C, Coiffec I, Ben Maamar M, Balaguer P, Kristensen DM, Chevrier C, Lavoué V, Poulain P, Dejucq-Rainsford N, Jégou B. Mazaud-Guittot S, et al. Among authors: jegou b. J Clin Endocrinol Metab. 2013 Nov;98(11):E1757-67. doi: 10.1210/jc.2013-2531. Epub 2013 Sep 12. J Clin Endocrinol Metab. 2013. PMID: 24030937
Human testis steroidogenesis is inhibited by phthalates.
Desdoits-Lethimonier C, Albert O, Le Bizec B, Perdu E, Zalko D, Courant F, Lesné L, Guillé F, Dejucq-Rainsford N, Jégou B. Desdoits-Lethimonier C, et al. Among authors: jegou b. Hum Reprod. 2012 May;27(5):1451-9. doi: 10.1093/humrep/des069. Epub 2012 Mar 8. Hum Reprod. 2012. PMID: 22402212
255 results