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Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform.
Pun FW, Liu BHM, Long X, Leung HW, Leung GHD, Mewborne QT, Gao J, Shneyderman A, Ozerov IV, Wang J, Ren F, Aliper A, Bischof E, Izumchenko E, Guan X, Zhang K, Lu B, Rothstein JD, Cudkowicz ME, Zhavoronkov A. Pun FW, et al. Among authors: izumchenko e. Front Aging Neurosci. 2022 Jun 28;14:914017. doi: 10.3389/fnagi.2022.914017. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35837482 Free PMC article.
Common pathway signature in lung and liver fibrosis.
Makarev E, Izumchenko E, Aihara F, Wysocki PT, Zhu Q, Buzdin A, Sidransky D, Zhavoronkov A, Atala A. Makarev E, et al. Among authors: izumchenko e. Cell Cycle. 2016 Jul 2;15(13):1667-73. doi: 10.1080/15384101.2016.1152435. Epub 2016 Jun 7. Cell Cycle. 2016. PMID: 27267766 Free PMC article.
In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development.
Ozerov IV, Lezhnina KV, Izumchenko E, Artemov AV, Medintsev S, Vanhaelen Q, Aliper A, Vijg J, Osipov AN, Labat I, West MD, Buzdin A, Cantor CR, Nikolsky Y, Borisov N, Irincheeva I, Khokhlovich E, Sidransky D, Camargo ML, Zhavoronkov A. Ozerov IV, et al. Among authors: izumchenko e. Nat Commun. 2016 Nov 16;7:13427. doi: 10.1038/ncomms13427. Nat Commun. 2016. PMID: 27848968 Free PMC article.
In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia.
Makarev E, Schubert AD, Kanherkar RR, London N, Teka M, Ozerov I, Lezhnina K, Bedi A, Ravi R, Mehra R, Hoque MO, Sloma I, Gaykalova DA, Csoka AB, Sidransky D, Zhavoronkov A, Izumchenko E. Makarev E, et al. Among authors: izumchenko e. Cell Death Discov. 2017 May 22;3:17022. doi: 10.1038/cddiscovery.2017.22. eCollection 2017. Cell Death Discov. 2017. PMID: 28580171 Free PMC article.
Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells.
Pustovalova M, Astrelina ТA, Grekhova A, Vorobyeva N, Tsvetkova A, Blokhina T, Nikitina V, Suchkova Y, Usupzhanova D, Brunchukov V, Kobzeva I, Karaseva Т, Ozerov IV, Samoylov A, Bushmanov A, Leonov S, Izumchenko E, Zhavoronkov A, Klokov D, Osipov AN. Pustovalova M, et al. Among authors: izumchenko e. Aging (Albany NY). 2017 Nov 21;9(11):2397-2410. doi: 10.18632/aging.101327. Aging (Albany NY). 2017. PMID: 29165316 Free PMC article.
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
Ravi R, Noonan KA, Pham V, Bedi R, Zhavoronkov A, Ozerov IV, Makarev E, V Artemov A, Wysocki PT, Mehra R, Nimmagadda S, Marchionni L, Sidransky D, Borrello IM, Izumchenko E, Bedi A. Ravi R, et al. Among authors: izumchenko e. Nat Commun. 2018 Feb 21;9(1):741. doi: 10.1038/s41467-017-02696-6. Nat Commun. 2018. PMID: 29467463 Free PMC article.
Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor.
Solanki HS, Raja R, Zhavoronkov A, Ozerov IV, Artemov AV, Advani J, Radhakrishnan A, Babu N, Puttamallesh VN, Syed N, Nanjappa V, Subbannayya T, Sahasrabuddhe NA, Patil AH, Prasad TSK, Gaykalova D, Chang X, Sathyendran R, Mathur PP, Rangarajan A, Sidransky D, Pandey A, Izumchenko E, Gowda H, Chatterjee A. Solanki HS, et al. Among authors: izumchenko e. Oncoscience. 2018 Feb 23;5(1-2):21-38. doi: 10.18632/oncoscience.395. eCollection 2018 Jan. Oncoscience. 2018. PMID: 29556515 Free PMC article.
Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.
Cortese F, Klokov D, Osipov A, Stefaniak J, Moskalev A, Schastnaya J, Cantor C, Aliper A, Mamoshina P, Ushakov I, Sapetsky A, Vanhaelen Q, Alchinova I, Karganov M, Kovalchuk O, Wilkins R, Shtemberg A, Moreels M, Baatout S, Izumchenko E, de Magalhães JP, Artemov AV, Costes SV, Beheshti A, Mao XW, Pecaut MJ, Kaminskiy D, Ozerov IV, Scheibye-Knudsen M, Zhavoronkov A. Cortese F, et al. Among authors: izumchenko e. Oncotarget. 2018 Feb 12;9(18):14692-14722. doi: 10.18632/oncotarget.24461. eCollection 2018 Mar 6. Oncotarget. 2018. PMID: 29581875 Free PMC article. Review.
PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40).
Subbannayya T, Leal-Rojas P, Zhavoronkov A, Ozerov IV, Korzinkin M, Babu N, Radhakrishnan A, Chavan S, Raja R, Pinto SM, Patil AH, Barbhuiya MA, Kumar P, Guerrero-Preston R, Navani S, Tiwari PK, Kumar RV, Prasad TSK, Roa JC, Pandey A, Sidransky D, Gowda H, Izumchenko E, Chatterjee A. Subbannayya T, et al. Among authors: izumchenko e. J Cell Commun Signal. 2019 Jun;13(2):163-177. doi: 10.1007/s12079-018-00503-5. Epub 2019 Jan 21. J Cell Commun Signal. 2019. PMID: 30666556 Free PMC article.
81 results