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Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi.
Martinez-Peinado N, Lorente-Macías Á, García-Salguero A, Cortes-Serra N, Fenollar-Collado Á, Ros-Lucas A, Gascon J, Pinazo MJ, Molina IJ, Unciti-Broceta A, Díaz-Mochón JJ, Pineda de Las Infantas Y Villatoro MJ, Izquierdo L, Alonso-Padilla J. Martinez-Peinado N, et al. Among authors: izquierdo l. Pharmaceuticals (Basel). 2021 Jul 1;14(7):638. doi: 10.3390/ph14070638. Pharmaceuticals (Basel). 2021. PMID: 34358064 Free PMC article.
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response.
Pinazo MJ, Posada Ede J, Izquierdo L, Tassies D, Marques AF, de Lazzari E, Aldasoro E, Muñoz J, Abras A, Tebar S, Gallego M, de Almeida IC, Reverter JC, Gascon J. Pinazo MJ, et al. Among authors: izquierdo l. PLoS Negl Trop Dis. 2016 Jan 4;10(1):e0004269. doi: 10.1371/journal.pntd.0004269. eCollection 2016 Jan. PLoS Negl Trop Dis. 2016. PMID: 26727000 Free PMC article.
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
Torrico F, Gascon J, Ortiz L, Alonso-Vega C, Pinazo MJ, Schijman A, Almeida IC, Alves F, Strub-Wourgaft N, Ribeiro I; E1224 Study Group. Torrico F, et al. Lancet Infect Dis. 2018 Apr;18(4):419-430. doi: 10.1016/S1473-3099(17)30538-8. Epub 2018 Jan 16. Lancet Infect Dis. 2018. PMID: 29352704 Free PMC article. Clinical Trial.
Purification of Glycosylphosphatidylinositol-Anchored Mucins from Trypanosoma cruzi Trypomastigotes and Synthesis of α-Gal-Containing Neoglycoproteins: Application as Biomarkers for Reliable Diagnosis and Early Assessment of Chemotherapeutic Outcomes of Chagas Disease.
Ortega-Rodriguez U, Portillo S, Ashmus RA, Duran JA, Schocker NS, Iniguez E, Montoya AL, Zepeda BG, Olivas JJ, Karimi NH, Alonso-Padilla J, Izquierdo L, Pinazo MJ, de Noya BA, Noya O, Maldonado RA, Torrico F, Gascon J, Michael K, Almeida IC. Ortega-Rodriguez U, et al. Among authors: izquierdo l. Methods Mol Biol. 2019;1955:287-308. doi: 10.1007/978-1-4939-9148-8_22. Methods Mol Biol. 2019. PMID: 30868536 Free PMC article.
Compounds targeting GPI biosynthesis or N-glycosylation are active against Plasmodium falciparum.
Fenollar À, Ros-Lucas A, Pía Alberione M, Martínez-Peinado N, Ramírez M, Ángel Rosales-Motos M, Y Lee L, Alonso-Padilla J, Izquierdo L. Fenollar À, et al. Among authors: izquierdo l. Comput Struct Biotechnol J. 2022 Feb 2;20:850-863. doi: 10.1016/j.csbj.2022.01.029. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35222844 Free PMC article.
A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease.
Montoya AL, Carvajal EG, Ortega-Rodriguez U, Estevao IL, Ashmus RA, Jankuru SR, Portillo S, Ellis CC, Knight CD, Alonso-Padilla J, Izquierdo L, Pinazo MJ, Gascon J, Suarez V, Watts DM, Malo IR, Ramsey JM, Alarcón De Noya B, Noya O, Almeida IC, Michael K. Montoya AL, et al. Among authors: izquierdo l. Molecules. 2022 Sep 5;27(17):5714. doi: 10.3390/molecules27175714. Molecules. 2022. PMID: 36080480 Free PMC article.
362 results